›› 2020, Vol. 40 ›› Issue (6): 550-553.

• 综述 • 上一篇    下一篇

整合素αvβ6与牙周炎关系的研究进展

王博1,毕良佳2   

  1. 1. 哈尔滨医科大学附属第四医院
    2. 哈尔滨医科大学附属第四医院 口腔科
  • 收稿日期:2019-08-21 修回日期:2019-10-17 出版日期:2020-06-28 发布日期:2020-06-28
  • 通讯作者: 毕良佳 E-mail:1798781661@qq.com
  • 基金资助:
    声动力诱导牙菌斑中牙龈卟啉单胞菌的脂质与DNA氧化的机制研究

Research progress of the relationship between integrin αvβ6 and periodontitis

Bo WANG1,jia liangBI   

  • Received:2019-08-21 Revised:2019-10-17 Online:2020-06-28 Published:2020-06-28
  • Contact: jia liangBI E-mail:1798781661@qq.com

摘要: 整联蛋白是一种细胞表面受体,参与调节包括细胞增殖,迁移,存活,组织侵袭和先天免疫等多种细胞行为,已有报道整合素β6基因(ITGB6)缺乏小鼠表现明显的牙周炎症,整合素αvβ6与转化生长因子-β1(TGF-β1)两种分子之间的相互作用在抑制炎症方面发挥重要作用,因此本文主要论述整合素αvβ6与牙周炎之间的关系。

关键词: 牙周炎, 整合素αvβ6, 转化生长因子-β1

Abstract: Integrins are cell surface receptors involved in the regulation of a variety of cellular behaviors including cell proliferation, migration, survival, tissue invasion and innate immunity.It has been reported that mice lacking integrin β6 gene (ITGB6) show significant periodontal inflammation.The interaction between integrin αvβ6 and transforming growth factor-β1 (TGF-β1) plays an important role in inhibiting inflammation.Therefore, this paper mainly discusses the relationship between integrin αvβ6 and periodontitis.

Key words: periodontitis, integrin αvβ6, transforming growth factor-β1

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