糖尿病与牙髓组织病变关系的研究现状

摘要/Abstract

摘要： 糖尿病（diabetes mellitus，DM）是一类全球日益流行的以高血糖为特征的系统性代谢性疾病。DM患者长期高血糖可引起视网膜、肾脏、心血管系统、皮肤及多种口腔组织结构与功能异常，进而导致相应并发症的发生。如今国内外越来越多的证据显示，DM也能够影响牙髓组织的结构与功能。该文拟对DM与牙髓组织病变关系的研究现状作一综述，以期为完善DM患者活髓保存的诊治策略提供理论基础。

关键词: 糖尿病, 牙髓, 病理改变, 组织修复

Abstract: Diabetes mellitus (DM), increasingly prevalent worldwide, is a group of systemic metabolic disease characterized by hyperglycemia. Long-term hyperglycemia can cause abnormal structure and impaired functions in various tissues and organs involving retina, kidney, cardiovascular system, skin, and oral tissues, which leads to multiple diabetic complications. Nowadays, emerging evidences have indicated that DM can also affect the structure and function of dental pulp tissue. This review aims to detail and analyze various fragments of current literature on the effect of diabetes on the relationship between diabetes and dental pulp lesions in a systematic and synoptic manner as much as possible, therefore providing theoretical basis for the diagnosis and treatment strategy of vital pulp therapy by diabetics.

Key words: diabetes, dental pulp, pathological changes, tissue repair

中图分类号:

陶硕张旗. 糖尿病与牙髓组织病变关系的研究现状[J]. 口腔医学, 2020, 40(7): 644-647.

Shuo TAO. The state of art research findings on the relationship between diabetes and dental pulp lesions[J]. Stomatology, 2020, 40(7): 644-647.

参考文献 35

[1]	Skyler J S, Bakris G L, Bonifacio E, et al. Differentiation of diabetes by pathophysiology, natural history, and prognosis[J]. Diabetes, 2017, 66(2): 241-255.
[2]	Forbes J M and Cooper M E. Mechanisms of diabetic complications[J]. Physiol Rev, 2013, 93(1): 137-188.
[3]	Lima S M F, Grisi D C, Kogawa E M, et al. Diabetes mellitus and inflammatory pulpal and periapical disease: a review[J]. Int Endod J, 2013, 46(8): 700-709.
[4]	Bender I and Bender A. Diabetes mellitus and the dental pulp[J]. J Endod, 2003, 29(6): 383-389.
[5]	王晓丽, 杨长怡, 张遵, et al. 糖尿病患者牙髓组织微血管病变的超微结构观察[J]. 上海口腔医学, 2012, 21(5): 506-510.
[6]	Moraru A I, GheorghiTa L M, Dascalu I T, et al. Histological and immunohistochemical study on the dental pulp of patients with diabetes mellitus[J]. Rom J Morphol Embryol, 2017, 58(2): 493-499.
[7]	Inagaki Y, Yoshida K, Ohba H, et al. High glucose levels increase osteopontin production and pathologic calcification in rat dental pulp tissues[J]. J Endod, 2010, 36(6): 1014-1020.
[8]	Garber S E, Shabahang S, Escher A P, et al. The effect of hyperglycemia on pulpal healing in rats[J]. J Endod, 2009, 35(1): 60-62.
[9]	Nakajima Y, Inagaki Y, Kido J, et al. Advanced glycation end products increase expression of S100A8 and A9 via RAGE-MAPK in rat dental pulp cells[J]. Oral Dis, 2015, 21(3): 328-334.
[10]	Leite M F, De Lima A, Massuyama M M, et al. In vivo astaxanthin treatment partially prevents antioxidant alterations in dental pulp from alloxan-induced diabetic rats[J]. Int Endod J, 2010, 43(11): 959-967.
[11]	Bender I B, Seltzer S, and Freedland J. The relationship of systemic diaseases to endodontic failures and treatment procedures[J]. Oral Surg Oral Med Oral Pathol, 1963, 16: 1102-1115.
[12]	Burket L W, Burket’s oral medicine. 5th ed. 1965, Philadelphia: JB Lippincott Co.
[13]	Russell B G. The dental pulp in diabetes mellitus[J]. Acta Pathol Microbiol Scand, 1967, 70(2): 319-320.
[14]	Bissada N F and Sharawy A M. Histologic study of gingival and pulpal vascular changes in human diabetics[J]. Egypt Dent J, 1970, 16(4): 283-296.
[15]	Amatyakul S, Chakraphan D, Chotipaibulpan S, et al. Role of exercise training on pulpal blood flow in diabetic rats[J]. Clin Hemorheol Microcirc, 2006, 34(1-2): 295-301.
[16]	Amatyakul S, Chakraphan D, Chotpaibulpan S, et al. The effect of long-term supplementation of vitamin C on pulpal blood flow in streptozotocin-induced diabetic rats[J]. Clin Hemorheol Microcirc, 2003, 29(3-4): 313-319.
[17]	Catanzaro O, Dziubecki D, Lauria L C, et al. Diabetes and its effects on dental pulp[J]. J Oral Sci, 2006, 48(4): 195-199.
[18]	Valikangas L, Pekkala E, Larmas M, et al. The effects of high levels of glucose and insulin on type I collagen synthesis in mature human odontoblasts and pulp tissue in vitro[J]. Adv Dent Res, 2001, 15: 72-75.
[19]	Lee Y H, Kim H S, Kim J S, et al. C-myb regulates autophagy for pulp vitality in glucose oxidative stress[J]. J Dent Res, 2016, 95(4): 430-438.
[20]	R?escu M, P?troi G, Constantinescu M V, et al. Clinical study of pulp capping in diabetes patients[J]. J Stomat Occ Med, 2010, 3(1): 20-22.
[21]	Yeh C K, Harris S E, Mohan S, et al. Hyperglycemia and xerostomia are key determinants of tooth decay in type 1 diabetic mice[J]. Lab Invest, 2012, 92(6): 868-882.
[22]	Kanafi M M, Ramesh A, Gupta P K, et al. Influence of hypoxia, high glucose, and low serum on the growth kinetics of mesenchymal stem cells from deciduous and permanent teeth[J]. Cells Tissues Organs, 2013, 198(3): 198-208.
[23]	Cintra L T A, Ferreira L L, Benetti F, et al. The effect of dental bleaching on pulpal tissue response in a diabetic animal model[J]. Int Endod J, 2017, 50(8): 790-798.
[24]	Ferreira L L, Gomes-Filho J E, Benetti F, et al. The effect of dental bleaching on pulpal tissue response in a diabetic animal model: a study of immunoregulatory cytokines[J]. Int Endod J, 2018, 51(3): 347-356.
[25]	Abbassy M A, Watari I, Bakry A S, et al. Diabetes detrimental effects on enamel and dentine formation[J]. J Dent, 2015, 43(5): 589-596.
[26]	杨立勇. 低度慢性炎症与2型糖尿病[J]. 中华糖尿病杂志, 2013, 5(9): 527-530.
[27]	Kolb H and Mandrup-Poulsen T. The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation[J]. Diabetologia, 2010, 53(1): 10-20.
[28]	Bonnet F and Scheen A J. Effects of SGLT2 inhibitors on systemic and tissue low-grade inflammation: The potential contribution to diabetes complications and cardiovascular disease[J]. Diabetes Metab, 2018, 44(6): 457-464.
[29]	Falanga V. Wound healing and its impairment in the diabetic foot[J]. The Lancet, 2005, 366(9498): 1736-1743.
[30]	王晓丽, 杨长怡, 张遵, et al. 糖尿病患者牙髓组织病变及IL-8、VEGF表达的研究[J]. 口腔医学, 2013, 33(1): 13-16,63.
[31]	Brownlee M. Biochemistry and molecular cell biology of diabetic complications[J]. Nature, 2001, 414(6865): 813-820.
[32]	Leite M F, Ganzerla E, Marques M M, et al. Diabetes induces metabolic alterations in dental pulp[J]. J Endod, 2008, 34(10): 1211-1214.
[33]	Milosavljevic A, L D J, Toljic B, et al. Melatonin levels in human diabetic dental pulp tissue and its effects on dental pulp cells under hyperglycaemic conditions[J]. Int Endod J, 2018, 51(10): 1149-1158.
[34]	Lee Y H, Kim G E, Song Y B, et al. Davallialactone reduces inflammation and repairs dentinogenesis on glucose oxidase-induced stress in dental pulp cells[J]. J Endod, 2013, 39(11): 1401-1406.
[35]	Qin W, Gao X, Ma T, et al. Metformin enhances the differentiation of dental pulp cells into odontoblasts by activating AMPK signaling[J]. J Endod, 2018, 44(4): 576-584.