NELL-1促成骨和成软骨的作用机制及应用前景

摘要/Abstract

摘要： NELL-1（neural epidermal growth factor-like 1）是一种对骨软骨细胞系具有高度特异性的生长因子，因其局部诱导骨形成的效应而受到密切关注；另外，它还具有作为全身治疗药物的成骨潜能以及促软骨形成的功能。促成骨方面，NELL-1主要通过Runx、MAPK信号通路、经典Wnt信号通路起作用，和经典的成骨因子BMPs存在协同作用。最近几年，由于生物信息学和高通量RNA测序的不断进步，研究者也发现了NELL-1促成骨分化时RNA网络的潜在调控作用。而NELL-1的促软骨形成活性主要依赖于Runx3介导的Ihh信号转导。本文主要就NELL-1促进成骨和成软骨的相关机制，以及其在骨组织再生、软骨组织再生领域的应用作一综述。

关键词: NELL-1, 成骨分化, 成软骨分化, 骨质疏松, 骨关节炎

Abstract: NELL-1 (neural epidermal growth factor-like 1), as a growth factor with high specificity to osteochondrocyte cell line, has been paid close attention to because of its effect of inducing bone formation locally. In addition, it also has the osteogenic potential as a systemic therapeutic drug and the function of promoting cartilage formation. In terms of osteogenesis, NELL-1 mainly takes effect through Runx2, MAPK signaling pathway, and classical Wnt signaling pathway, and it has a synergistic effect with the classical osteogenic factor BMPs. In recent years, due to the continuous progress of bioinformatics and high-throughput RNA sequencing, researchers have also discovered the potential regulatory role of RNA network when NELL-1 promotes osteogenesis. The chondrogenic activity of NELL-1 mainly depends on the Ihh signal transduction mediated by Runx3. This article mainly reviews the related mechanisms of NELL-1 in promoting osteogenesis and chondrogenesis, and its application in the field of bone tissue regeneration and cartilage tissue regeneration.

Key words: NELL-1, osteogenesis, chondrogenesis, Osteoporosis, Osteoarthritis

中图分类号:

R780.2

胡诗余施洁珺胡济安. NELL-1促成骨和成软骨的作用机制及应用前景[J]. 口腔医学, 2021, 41(6): 545-550.

Shi-Yu HU. The action mechanism and application prospects of NELL-1 in promoting osteogenesis and chondrogenesis[J]. Stomatology, 2021, 41(6): 545-550.

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