唾液腺腺样囊性癌淋巴结转移相关的研究进展

›› 2021, Vol. 41 ›› Issue (6): 567-571.

唾液腺腺样囊性癌淋巴结转移相关的研究进展

张妮¹,刘洋²,张芳¹

1. 山西医科大学口腔医院
2. 山西医科大学口腔医学院·口腔医院

收稿日期:2020-09-16 修回日期:2020-12-08 出版日期:2021-06-28 发布日期:2021-06-25
通讯作者: 张芳 E-mail:doctor-fangzh@hotmail.com
基金资助:
山西省青年基金项目应用基础研究计划;山西医科大学博士创业基金

Research progress on the lymph node metastasis of salivary adenoid cystic carcinoma

Received:2020-09-16 Revised:2020-12-08 Online:2021-06-28 Published:2021-06-25
Supported by:
Youth Fund Project of Shanxi Applied Basic Research Program;Shanxi Medical University Doctoral Startup Fund

摘要/Abstract

摘要： 唾液腺腺样囊性癌（salivary adenoid cystic carcinoma，SACC）是一种常见的唾液腺恶性肿瘤，恶性度高，局部复发和远处转移是SACC患者常见的死亡原因。传统上认为淋巴结转移在SACC患者中并不常见，然而由于文献报道的转移发生率差别很大，SACC患者颈部治疗方案仍有争议，且SACC术中淋巴结清扫范围尚无统一标准。本文就唾液腺腺样囊性癌颈部淋巴结转移相关的临床病理学参数，治疗方案及相关分子标志物等情况作一综述，为临床上SACC淋巴结转移的早期发现和治疗方案提供参考。

关键词: 唾液腺腺样囊性癌, 淋巴结转移, 选择性颈部淋巴结清扫术

Abstract: Salivary adenoid cystic carcinoma (SACC) is one of the most common malignant tumors. High malignancy, local recurrence and distant metastasis are common causes of death among patients with SACC. Lymph node metastasis has traditionally been considered uncommon in patients with SACC. However, due to the great difference in the incidence of metastasis reported in the literature, the treatment of neck for patients with SACC still remains controversial and there is no uniform standard for the surgery scope of lymph node dissection. This paper aims to provide an overview of the research progress of clinical pathological features, treatment and molecular signature of cervical lymph node metastasis in salivary adenoid cystic carcinoma, hoping to provide theoretical basis for early detection and treatment of SACC lymph node metastasis.

Key words: Salivary adenoid cystic carcinoma, lymph node metastasis, selective neck dissection

中图分类号:

R739.87

张妮刘洋张芳. 唾液腺腺样囊性癌淋巴结转移相关的研究进展[J]. 口腔医学, 2021, 41(6): 567-571.

参考文献 38

[1]	Coca-Pelaz A, Rodrigo JP, Bradley PJ, et al.Adenoid cystic carcinoma of the head and neck – An update[J].Oral Oncol, 2015, 51(7):652-661
[2]	Bj?rndal K, Krogdahl A, Therkildsen MH, et al.Salivary adenoid cystic carcinoma in Denmark 1990-2005: Outcome and independent prognostic factors including the benefit of radiotherapyResults of the Danish Head and Neck Cancer Group (DAHANCA)[J].Oral Oncol, 2015, 51(12):1138-1142
[3]	Amit M, Binenbaum Y, Sharma K, et al.Incidence of cervical lymph node metastasis and its association with outcomes in patients with adenoid cystic carcinomaAn international collaborative study[J].Head Neck, 2015, 37(7):1032-1037
[4]	Min R, Siyi L, Wenjun Y, et al.Salivary gland adenoid cystic carcinoma with cervical lymph node metastasis: a preliminary study of 62 cases[J].Int J Oral Maxillofac Surg, 2012, 41(8):952-957
[5]	Tian Z, Li L, Wang L, et al.Salivary gland neoplasms in oral and maxillofacial regions: A 23-year retrospective study of 6982 cases in an eastern Chinese population[J].Int J Oral Maxillofac Surg, 2010, 39(3):235-242
[6]	Ning CL, Zhao TF, Wang ZC, et al.Cervical lymph node metastases in salivary gland adenoid cystic carcinoma: A systematic review and meta-analysis[J]. Cancer Manag Res, 2018, 10: 1677-1685.
[7]	Liu ZL, Fang Z, Dai TG, et al.Higher positive lymph node ratio indicates poorer distant metastasis–free survival in adenoid cystic carcinoma patients with nodal involvement[J].J Cranio - Maxillofac Surg, 2015, 43(6):751-757
[8]	Cao CN, Ge MH, Chen XZ, et al.Clinical outcomes and prognostic factors of salivary gland adenoid cystic carcinomas: A case control study[J].Oral Surg Oral Med Oral Pathol Oral Radiol, 2017, 123(5):531-535
[9]	Ko YH, Lee MA, Hong YS, et al.Prognostic factors affecting the clinical outcome of adenoid cystic carcinoma of the head and neck[J].Jpn J Clin Oncol, 2007, 37(11):805-811
[10]	Lee SY, Kim BH, Choi EC.Nineteen-year oncologic outcomes and the benefit of elective neck dissection in salivary gland adenoid cystic carcinoma[J].Head Neck, 2014, 36(12):1796-1801
[11]	张春叶, 邓旭霞, 田臻, 等.唾液腺腺样囊性癌例临床病理分析[J].中国口腔颌面外科杂志, 2014, 12(2):126-130
[12]	Han NN, Ong H, Liu ZH, et al.Lymph node involvement predicts poor prognosis in primary tongue adenoid cystic carcinoma: A preliminary study of 54 cases[J].J Cranio - Maxillofac Surg, 2017, 45(4):589-594
[13]	Megwalu UC, Sirjani D.Risk of nodal metastasis in major salivary gland adenoid cystic carcinoma[J].Otolaryngol - - Head Neck Surg, 2017, 156(4):660-664
[14]	朱子羽, 冯剑颖, 郑瑀心, 等.涎腺腺样囊性癌淋巴结转移影响因素及与预后关系分析[J].浙江医学, 2018, 40(14):1602-1605
[15]	张晔, 张妮, 刘晓筱, 等.唾液腺腺样囊性癌淋巴结转移相关的临床病理分析[J].北京大学学报医学版, 2020, 52(1):30-34
[16]	Meyers M, Granger B, Herman P, et al.Erratum to “Head and neck adenoid cystic carcinoma: A prospective multicenter REFCOR study of 95 cases” [EurAnn. Otorhinolaryngol. Head Neck Dis. 133 (1) (2016) 13-7[J].Eur Ann Otorhinolaryngol Head Neck Dis, 2016, 133(6):453-
[17]	Papaspyrou G, Hoch S, Rinaldo A, et al.Chemotherapy and targeted therapy in adenoid cystic carcinoma of the head and neck: A review[J].Head Neck, 2011, 33(6):905-911
[18]	Martins-Andrade B, dos Santos Costa SF, Sant' Ana MSP, et al.Prognostic importance of the lymphovascular invasion in head and neck adenoid cystic carcinoma: A systematic review and meta-analysis[J]. Oral Oncol, 2019, 93: 52-58.
[19]	Hellquist H, Skálová A, Barnes L, et al.Cervical lymph node metastasis in high-grade transformation of head and neck adenoid cystic carcinoma: A collective international review[J].Adv Ther, 2016, 33(3):357-368
[20]	Seethala RR, Altemani A, Ferris RL, et al.Data set for the reporting of carcinomas of the major salivary glands: Explanations and recommendations of the guidelines from the international collaboration on cancer reporting[J].Arch Pathol Lab Med, 2019, 143(5):578-586
[21]	Nagao T.dedifferentiation” and high-grade transformation in salivary gland carcinomas[J].Head Neck Pathol, 2013, 7(1):37-47
[22]	黄擎.唾液腺腺样囊性癌颈淋巴结转移规律的临床研究[J].中国肿瘤临床, 2016, 43(24):1094-1098
[23]	Costa AF, Altemani A, Vékony H, et al.Genetic profile of adenoid cystic carcinomas (ACC) with high-grade transformation versus solid type[J].Anal Cell Pathol Amsterdam, 2010, 33(5):217-228
[24]	Ouyang DQ, Liang LZ, Zheng GS, et al.Risk factors and prognosis for salivary gland adenoid cystic carcinoma in Southern China[J].Medicine, 2017, 96(5):e5964-
[25]	Oplatek A, Ozer E, Agrawal A, et al.Patterns of recurrence and survival of head and neck adenoid cystic carcinoma after definitive resection[J].Laryngoscope, 2010, 120(1):65-70
[26]	Poorten VV, Hunt J, Bradley PJ, et al.Recent trends in the management of minor salivary gland carcinoma[J].Head Neck, 2014, 36(3):444-455
[27]	Xiao R, Sethi RKV, Feng AL, et al.The role of elective neck dissection in patients with adenoid cystic carcinoma of the head and neck[J].Laryngoscope, 2019, 129(9):2094-2104
[28]	Lee SY, Shin HA, Rho KJ, et al.Characteristics,management of the neck,and oncological outcomes of malignant minor salivary gland tumours in the oral and sinonasal regions[J].Br J Oral Maxillofac Surg, 2013, 51(7):e142-e147
[29]	Qian ZJ, Chen MM, Divi V, et al.Impact of lymph node sampling on survival in cN0 major salivary gland adenoid cystic carcinoma[J].Head Neck, 2019, 41(6):1903-1907
[30]	Balamucki CJ, Amdur RJ, Werning JW, et al.Adenoid cystic carcinoma of the head and neck[J].Am J Otolaryngol, 2012, 33(5):510-518
[31]	Gomez DR, Hoppe BS, Wolden SL, et al.Outcomes and prognostic variables in adenoid cystic carcinoma of the head and neck: A recent experience[J].Int J Radiat Oncol Biol Phys, 2008, 70(5):1365-1372
[32]	Ettl T, Gosau M, Brockhoff G, et al.Predictors of cervical lymph node metastasis in salivary gland cancer[J].Head Neck, 2014, 36(4):517-523
[33]	Dai W, Zhou Q, Xu ZF, et al.Expression of TMPRSS4 in patients with salivary adenoid cystic carcinoma: Correlation with clinicopathological features and prognosis[J].Med Oncol, 2013, 30(4):1-7
[34]	Xu JJ, Zhu X, Li QL, et al.Loss of PIM1 correlates with progression and prognosis of salivary adenoid cystic carcinoma (SACC)[J]. Cancer Cell Int, 2018, 18: 22.
[35]	陈俊, 李姬梅, 李伟, 等.中期因子和微血管密度在涎腺腺样囊性癌组织中的表达[J].华西口腔医学杂志, 2016, 34(2):189-193
[36]	Fonseca FP, Sena Filho M, Altemani A, et al.Molecular signature of salivary gland tumors: Potential use as diagnostic and prognostic marker[J].J Oral Pathol Med, 2016, 45(2):101-110
[37]	de Almeida-Pinto YD, Costa SFDS, de Andrade BAB, et al.T(6;9)(MYB-NFIB) in head and neck adenoid cystic carcinoma: A systematic review with meta-analysis[J].Oral Dis, 2019, 25(5):1277-1282
[38]	de Bree R, Takes RP, Shah JP, et al.Elective neck dissection in oral squamous cell carcinoma: Past, present and future[J]. Oral Oncol, 2019, 90: 87-93.