牙髓干细胞的生物学性能及临床应用研究进展

doi:10.13591/j.cnki.kqyx.2022.01.001

口腔医学 ›› 2022, Vol. 42 ›› Issue (1): 1-7.doi: 10.13591/j.cnki.kqyx.2022.01.001

• 院士专栏 • 下一篇

牙髓干细胞的生物学性能及临床应用研究进展

李阳阳, 张茂林, 杨驰, 邹多宏, 张志愿

口腔疾病国家临床医学研究中心,上海市口腔医学重点实验室,上海交通大学医学院附属第九人民医院口腔外科,中国医学科学院口腔颌面再生医学创新单元,上海(200011)

修回日期:2021-09-08 出版日期:2022-01-28 发布日期:2022-01-28
通讯作者: 张志愿 E-mail:zhzhy0502@163.com
邹多宏 E-mail:zouduohongyy@163.com
作者简介:张志愿,男,中国工程院院士、医药卫生学部常委,中国医学科学院学部委员。上海交通大学光启讲席教授,主任医师,博士生导师;1998—2014年任上海交通大学医学院附属第九人民医院院长。现任国家级重点学科——口腔医学学科带头人,国家口腔医学中心主任,国家口腔疾病临床医学研究中心主任、上海市口腔医学重点实验室主任、上海市重中之重临床医学中心主任;中华口腔医学会名誉会长、中国抗癌协会常务理事、中国抗癌协会头颈肿瘤专业委员会名誉主委、上海市退(离)休高级专家协会会长;国际牙医学院、英国爱丁堡皇家外科学院和香港大学牙医学院fellowship。受聘为日本大阪齿科大学、空军军医大学客座教授;全国十三五规划教材《口腔颌面外科学》《口腔科学》主编,《上海口腔医学》主编,Frontiers of Oral and Maxillofacial Medicine名誉主编。
长期从事口腔颌面部肿瘤与血管畸形的临床与基础研究。已发表学术论文368篇(SCI收录158篇),尤其近年来完成了国内首个诱导化疗对中晚期口腔鳞癌前瞻性随机Ⅲ期临床试验,结果发表在J Clin Oncol杂志,连续六年荣列高被引中国学者。主编专著14部、副主编5部和参编专著12部(英文2部),第一负责人承担国家“863”、“十一五”支撑计划,国家自然科学基金重点2项、面上5项等部、委级课题共20余项;以第一完成人获得国家科学技术进步二等奖2项、国家教学成果奖二等奖、教育部提名国家科学技术奖自然科学奖二等奖等10余项。被卫生部评为“卫生部有突出贡献的中青年专家”。曾获何梁何利科学与技术进步奖、全国创新争先奖、全国优秀科技工作者、上海市十大科技精英等,已培养硕、博75名(获国家杰青、长江学者1人、国家科技部重大研发项目首席科学家1人、青年长江学者1人、中国科协 “托举计划”1人、上海市优秀学科带头人2人、上海市青年科技英才1人、上海市银蛇奖一、二等奖各1人,已有14人晋升交大医学院博导)。
基金资助:
我国口腔颌面再生医学成果转化与产业发展的战略研究(2019-XY-85);国家自然科学基金面上项目(31870969);上海交通大学医学院“双百人”人才计划(20191816);中国医学科学院医学与健康科技创新工程项目资助(2019-I2M-5-037);上海交通大学医学院附属第九人民医院“交叉”研究基金项目(JYJC202012);上海交通大学医学院附属第九人民医院生物样本库项目(YBKB201912)

Advances in studies on biological properties and pre-clinical application of dental pulp stem cells

LI Yangyang, ZHANG Maolin, YANG Chi, ZOU Duohong, ZHANG Zhiyuan

Department of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Stomatology; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences, Shanghai 200011, China

Revised:2021-09-08 Online:2022-01-28 Published:2022-01-28

摘要/Abstract

摘要： 牙髓干细胞是一类具有自我更新、多向分化、高度增殖能力的外胚间充质干细胞,可为组织器官修复和多种疾病治疗提供细胞来源。本文通过总结相关文献,对牙髓干细胞的一般生物学特性进行论述,并探讨其成骨/成牙本质、成肌/成血管和神经再生的机制,以及其在糖尿病和眼部疾患的临床前应用。同时结合了国内外有关牙髓干细胞的最新临床应用进展,给未来牙髓干细胞实现更广阔的临床转化应用提供理论及临床实践参考。

关键词: 牙髓干细胞, 生物学特性, 临床前应用

Abstract: Dental pulp stem cells are a kind of ecto-mesenchymal stem cells with the ability of self-renewal, multidirectional differentiation and high proliferation, which can be used as a cell source for tissue and organ repair and treatment of many diseases. In this review, the general biological characteristics of dental pulp stem cells are reviewed, and the mechanisms of osteoblast/odontoblast, myoblast/angiogenesis, and nerve regeneration as well as their preclinical applications in diabetes mellitus and ocular diseases are discussed. At the same time, combined with the latest clinical application progress of dental pulp stem cells at home and abroad, this review is aimed to provide theoretical and clinical practice reference for broader clinical application of dental pulp stem cells in the future.

Key words: dental pulp stem cell, biological characteristic, preclinical application

中图分类号:

李阳阳, 张茂林, 杨驰, 邹多宏, 张志愿. 牙髓干细胞的生物学性能及临床应用研究进展[J]. 口腔医学, 2022, 42(1): 1-7.

LI Yangyang, ZHANG Maolin, YANG Chi, ZOU Duohong, ZHANG Zhiyuan. Advances in studies on biological properties and pre-clinical application of dental pulp stem cells[J]. Stomatology, 2022, 42(1): 1-7.

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牙髓干细胞的生物学性能及临床应用研究进展

Advances in studies on biological properties and pre-clinical application of dental pulp stem cells

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