口腔医学 ›› 2022, Vol. 42 ›› Issue (3): 256-260.doi: 10.13591/j.cnki.kqyx.2022.03.013

• 综述 • 上一篇    下一篇

壳聚糖促进牙釉质仿生矿化修复的研究进展

唐震航, 陈卓   

  1. 浙江大学医学院附属口腔医院牙体牙髓科,浙江省口腔生物医学研究重点实验室,浙江杭州(310006)
  • 修回日期:2021-08-03 出版日期:2022-03-28 发布日期:2022-03-21
  • 通讯作者: 陈 卓 Tel:(0571)87217437 E-mail:zoechen@zju.edu.cn
  • 基金资助:
    国家重点研发计划(2018YFC1105100)

Research progress of chitosan promoting enamel biomimetic mineralization

TANG Zhenhang, CHEN Zhuo   

  1. Department of Endodontics, the Affiliated Hospital of Stomatology, School of Stomatology, Zhejiang University School of Medicine, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Hangzhou 310006, China
  • Revised:2021-08-03 Online:2022-03-28 Published:2022-03-21

摘要: 牙釉质的仿生矿化是口腔材料学关注的热点问题。壳聚糖是一种天然的阳离子多糖,它与牙釉质细胞外基质成分具有相似的化学结构和生物学行为。壳聚糖及其衍生物的优异生物相容性和聚电解质作用等使其成为一种非常合适的载体或有机模板。近年来,壳聚糖有机-无机复合材料已应用于牙釉质仿生矿化修复。该文就壳聚糖促进牙釉质仿生矿化原理及其在牙釉质修复中的应用的研究进展作一综述。

关键词: 壳聚糖, 仿生矿化, 牙釉质

Abstract: Enamel biomimetic mineralization is a significant issue in the science of dental materials. Chitosan is a natural cationic polysaccharide, whose chemical structure and biological behaviors are similar to components of the extracellular matrix of enamel. Its excellent biocompatibility and polyelectrolyte action make it a suitable carrier or an organic template. In recent years, chitosan-based biomimetic organic-inorganic composite materials have been applied in the field of enamel biomimetic mineralization. This is mainly focused on the basic theories and applications of chitosan in promoting enamel biomimetic mineralization.

Key words: chitosan, biomimetic mineralization, enamel

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