人β防御素2与口腔扁平苔藓相关性的研究进展

doi:10.13591/j.cnki.kqyx.2022.03.017

摘要/Abstract

摘要： 口腔扁平苔藓(oral lichen planus,OLP)是一种常见的口腔黏膜慢性免疫性炎症疾病,OLP的病因和发病机理目前尚未阐明,在临床诊疗过程中存在着诸多问题且OLP存在癌变风险,故OLP的发生发展及临床诊疗方面的研究历来受到重视。近年来的一些研究表明,OLP的发生与人β防御素2(human β defensin-2,hBD-2)有着密切关系。该文就OLP与hBD-2的相关研究进展进行总结及分析。

关键词: 人β防御素2, 口腔扁平苔藓, 抗菌肽, 白念珠菌

Abstract: Oral lichen planus (OLP) is a common chronic immune inflammatory disease that affects oral mucosa. However, the exact etiology of OLP has not yet been elucidated and valid diagnosis and treatment for OLP is inhibited by some factors with OLP itself a risk factor for malignant transformation. Therefore, research on the pathogenesis of OLP and treatment for OLP has been receiving much attention. In recent years, some studies have shown that OLP is closely related to human β defensin-2 (hBD-2). This paper attempts to summarize and analyze recent research progress of OLP and hBD-2.

Key words: human β defensin-2, oral lichen planus, antimicrobial peptide, Candida albicans

中图分类号:

R781.5

黄辛兆, 钟良军. 人β防御素2与口腔扁平苔藓相关性的研究进展[J]. 口腔医学, 2022, 42(3): 276-279.

HUANG Xinzhao, ZHONG Liangjun. Research advances in the relationship between human β defensin-2 and oral lichen planus[J]. Stomatology, 2022, 42(3): 276-279.

参考文献

[1] Schröder JM, Harder J. Human beta-defensin-2[J].Int J Biochem Cell Biol, 1999, 31(6):645-651.
[2] Harder J, Bartels J, Christophers E,et al. A peptide antibiotic from human skin[J]. Nature, 1997, 387(6636):861.
[3] Katagiri S, Park K, Maeda Y,et al. Overexpressing IRS1 in endothelial cells enhances angioblast differentiation and wound healing in diabetes and insulin resistance[J]. Diabetes, 2016, 65(9):2760-2771.
[4] 郭峰, 李涛, 韩燃, 等. 人β防御素1～4抑菌及盐敏感性研究[J]. 安徽医科大学学报, 2013, 48(8):885-889.
[5] Wilmes M, Cammue BP, Sahl HG,et al. Antibiotic activities of host defense peptides:More to it than lipid bilayer perturbation[J]. Nat Prod Rep, 2011, 28(8):1350-1358.
[6] Kim J, Yang YL, Jang YS. Human β-defensin 2 is involved in CCR2-mediated Nod2 signal transduction, leading to activation of the innate immune response in macrophages[J]. Immunobiology, 2019, 224(4):502-510.
[7] BiragynA, Ruffini PA, Leifer CA, et al. Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2[J]. Science, 2002, 298(5595):1025-1029.
[8] Ghosh SK, McCormick TS, Weinberg A. Human beta defensins and cancer:Contradictions and common ground[J]. Front Oncol, 2019, 9:341.
[9] Bautista-Hernández LA, Gómez-Olivares JL, Buentello-Volante B,et al. Fibroblasts:The unknown sentinels eliciting immune responses against microorganisms[J]. Eur J Microbiol Immunol (Bp), 2017, 7(3):151-157.
[10] Langfeldt D, Neulinger SC, Stiesch M,et al. Health- and disease-associated species clusters in complex natural biofilms determine the innate immune response in oral epithelial cells during biofilm maturation[J]. FEMS Microbiol Lett, 2014, 360(2):137-143.
[11] 郭贤利. 人β防御素2重组蛋白体外抑菌实验及抗肿瘤细胞毒性探究[J]. 现代医学与健康研究电子杂志, 2018, 2(11):177,179.
[12] Nittayananta W. Oral fungi in HIV:Challenges in antifungal therapies[J]. Oral Dis, 2016, 22(Suppl 1):107-113.
[13] Abiko Y, Jinbu Y, Noguchi T,et al. Upregulation of human beta-defensin 2 peptide expression in oral lichen planus, leukoplakia and candidiasis. An immunohistochemical study[J]. Pathol Res Pract, 2002, 198(8):537-542.
[14] 邹杰. 口腔扁平苔藓患者hBD2和LL-37的表达与口腔白色念珠菌的相关关系研究[D]. 南宁:广西医科大学, 2006.
[15] 刘东娟, 陈谦明. 口腔扁平苔藓的诊断与治疗[J]. 中国实用口腔科杂志, 2017, 10(9):518-521,525.
[16] 王雪薇, 唐楠, 赵知白, 等. 口腔扁平苔藓黏膜病损区微生物群落分析[J]. 口腔医学, 2020, 40(2):108-112.
[17] Carvalho MFMS, Cavalieri D, Do Nascimento S,et al. Cytokines levels and salivary microbiome play a potential role in oral lichen planus diagnosis[J]. Sci Rep, 2019, 9(1):18137.
[18] Wang XW, Zhao ZB, Tang N,et al. Corrigendum: Microbial community analysis of saliva and biopsies in patients with oral lichen planus[J]. Front Microbiol, 2020, 11:1282.
[19] Szukiewicz D, Alkhalayla H, Pyzlak M,et al. Human beta-defensin 1, 2 and 3 production by amniotic epithelial cells with respect to human papillomavirus (HPV) infection, HPV oncogenic potential and the mode of delivery[J]. MicrobPathog, 2016, 97:154-165.
[20] 赵雯雯, 毕庆伟, 李岩, 等. 口腔扁平苔藓患者黏膜脱落上皮中人β防御素-2和白色念珠菌的研究[J]. 医学研究杂志, 2016, 45(7):92-95.
[21] Ellepola AN, Samaranayake LP. Inhalational and topical steroids, and oral candidosis:A mini review[J]. Oral Dis, 2001, 7(4):211-216.
[22] Lodi G, Tarozzi M, Sardella A,et al. Miconazole as adjuvant therapy for oral lichen planus:A double-blind randomized controlled trial[J]. Br J Dermatol, 2007, 156(6):1336-1341.
[23] Casaroto AR, da Silva RA, Salmeron S,et al. Candida albicans-cell interactions activate innate immune defense in human palate epithelial primary cells via nitric oxide (NO) and β-defensin 2 (hBD-2)[J]. Cells, 2019, 8(7):E707.
[24] 黄韵颖, 周塑,蔡扬. 口腔扁平苔藓患者血清中白细胞介素-12和白细胞介素-27表达与免疫功能的相关性[J]. 华西口腔医学杂志, 2016, 34(2):140-144.
[25] 王安训. 口腔黏膜相关疾病免疫功能检测及意义[J]. 口腔疾病防治, 2021, 29(2):73-80.
[26] Chiang CP, Yu-Fong Chang J, Wang YP, et al. Oral lichen planus-Differential diagnoses, serum autoantibodies, hematinic deficiencies, and management[J].Taiwan Yi Zhi, 2018, 117(9):756-765.
[27] DeAngelis LM, Cirillo N, McCullough MJ. The immunopathogen-esis of oral lichen planus-Is there a role for mucosal associated invariant T cells?[J]. J Oral Pathol Med, 2019, 48(7):552-559.
[28] Mutafchieva MZ, Draganova-Filipova MN, Zagorchev PI,et al. Oral lichen planus-known and unknown:A review[J]. Folia Med (Plovdiv), 2018, 60(4):528-535.
[29] Giuliani M, Troiano G, Cordaro M,etal. Rate of malignant transformation of oral lichen planus:A systematic review[J]. Oral Dis, 2019, 25(3):693-709.
[30] Idrees M, Kujan O, Shearston K,etal. Oral lichen planus has a very low malignant transformation rate:A systematic review and meta-analysis using strict diagnostic and inclusion criteria[J]. J Oral Pathol Med, 2021, 50(3):287-298.
[31] Jayaraj R, Shetty SS, Kumaraswamy C,et al. Clinical interpreta-tion of findings from a systematic review and a comprehensive meta-analysis on clinicopathological and prognostic characteristics of oral squamous cell carcinomas (OSCC) arising in patients with oral lichen planus (OLP)[J]. Oral Oncol, 2020, 108:104974.
[32] Gainza-Cirauqui ML, Nieminen MT, Novak Frazer L ,et al. Production of carcinogenic acetaldehyde by Candida albicans from patients with potentially malignant oral mucosal disorders[J]. J Oral Pathol Med. 2013, 42(3):243-249.
[33] Alburquenque C, Amaro J, Fuentes M,et al. Protective effect of inactivated blastoconidia in keratinocytes and human reconstituted epithelium against C. albicans infection[J]. Med Mycol, 2019, 57(4):457-467.
[34] Kesting MR, Mueller C, Wagenpfeil S,et al. Quantitative comparison of the expression of antimicrobial peptides in the oral mucosa and extraoral skin[J]. Br J Oral Maxillofac Surg, 2012, 50(5):447-453.
[35] 米博斌. 改良型人源性防御素2通过诱导角质细胞增殖和迁移促进创面愈合[D]. 武汉:华中科技大学, 2019.