m6A甲基化修饰参与成骨分化调控的研究进展

doi:10.13591/j.cnki.kqyx.2022.07.016

摘要/Abstract

摘要： N⁶-甲基腺苷(m⁶A)是真核生物中含量最丰富的表观遗传修饰,在哺乳动物生长发育和疾病控制中起着至关重要的作用。无论生理或者病理状态下,m⁶A 修饰均可以对骨骼发育重塑相关的基因表达进行精准调控,进而影响骨代谢平衡。该文总结了m⁶A修饰在成骨分化过程中的调控机制,为促进骨形成和预防治疗骨代谢相关疾病提供新思路和潜在靶点。

关键词: m⁶A修饰, RNA甲基化, 成骨分化, 调控机制

Abstract: N⁶-methyladenosine (m⁶A) is the most abundant epigenetic modification in eukaryotes and plays a significant regulatory role in mammalian growth and disease control. Studies have found that m⁶A modification can accurately regulate the gene expression related to bone remodeling and development no matter in a physiological or pathological state, thus affecting bone metabolism balance. In this systematic review, we summarized regulatory mechanisms of m⁶A modification in osteogenic differentiation, in order to provide new ideas and potential targets for promoting bone formation and preventing or treating diseases related to bone metabolism.

Key words: m⁶A modification, RNA methylation, osteogenic differentiation, regulatory mechanism

中图分类号:

张校晨, 孙唯夫, 方世殊, 秦文, 金作林. m⁶A甲基化修饰参与成骨分化调控的研究进展[J]. 口腔医学, 2022, 42(7): 655-658.

ZHANG Xiaochen, SUN Weifu, FANG Shishu, QIN Wen, JIN Zuolin. Research progress of N⁶-methyladenosine in regulating osteogenic differentiation[J]. Stomatology, 2022, 42(7): 655-658.

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m⁶A甲基化修饰参与成骨分化调控的研究进展

Research progress of N⁶-methyladenosine in regulating osteogenic differentiation

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