小分子化合物促进牙髓牙本质复合体损伤修复的研究进展

doi:10.13591/j.cnki.kqyx.2023.03.013

摘要/Abstract

摘要：

龋病、外伤、医源性刺激等均可引起牙髓牙本质复合体损伤,保存活髓、促进牙髓牙本质复合体的损伤修复对临床治疗至关重要。近年来研究发现,各类小分子化合物可通过细胞内关键信号通路和代谢途径等机制调控炎症,促进牙髓干细胞迁移、增殖、分化,促进血管、神经再生,从而促进牙髓牙本质复合体的损伤修复。该文旨在对近年来小分子化合物在促进牙髓牙本质复合体损伤修复中的应用研究作一综述。

关键词: 牙髓牙本质复合体, 组织修复, 小分子化合物

Abstract:

Dental caries, trauma, and iatrogenic stimulation can cause damage to the dentin-pulp complex. Preserving the viable pulp and promoting damage repair of the dentin-pulp complex is of great clinical significance at present. In recent years, studies have found that various small molecular compounds can regulate inflammation, promote the migration, proliferation, and differentiation of dental pulp stem cells, promote blood vessel, nerve regeneration and other biological processes by regulating key intracellular signaling pathways and metabolic pathways, and could thereby promote damage repair of the dentin-pulp complex. The objective of this paper is to review recent research on various small molecular compounds used in promoting the repair of dentin-pulp complex.

Key words: dentin-pulp complex, tissue repair, small molecule compound

中图分类号:

R781.3

邵皎皎, 张旗. 小分子化合物促进牙髓牙本质复合体损伤修复的研究进展[J]. 口腔医学, 2023, 43(3): 256-261.

SHAO Jiaojiao, ZHANG Qi. Application of small molecular compounds in promoting the repair of dentin-pulp complex injury[J]. Stomatology, 2023, 43(3): 256-261.

图/表 1

参考文献 62

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作者	发表时间	载药生物材料	辛伐他汀含量	实验动物
Chang等^[53]	2020年	磷酸钙-硫酸钙双相骨水泥	-	比格犬
张杨安等^[54]	2019年	胶原蛋白复合海绵	1 μmol/L	SD大鼠
Dianat等^[55]	2018年	甲基纤维素凝胶	5 mg/mL 15 mg/mL	大鼠
王珂等^[56]	2016年	羟基磷灰石中空微球	100 nmol/L	Wistar大鼠
祝雪芳等^[57]	2015年	壳聚糖温敏性凝胶	1~25 μg/mL	Wistar大鼠