联合生物材料的牙源性间充质干细胞进行牙周组织再生的研究进展

doi:10.13591/j.cnki.kqyx.2023.03.014

摘要/Abstract

摘要：

牙周炎治疗的终极目标是实现牙周组织结构及功能的再生,但现有牙周组织再生方法仍难以完整再生牙周组织层次结构。而干细胞因其自我更新及多向分化的潜能,为牙周再生提供新的可能,基于干细胞的组织工程也因此越来越受到关注。该文就联合生物材料的牙源性干细胞进行牙周组织再生的研究进展作综述,指出自体干细胞移植应用受到供体来源的限制,后续研究应围绕发展多相支架材料及尝试建立干细胞库等方面展开。

关键词: 间充质干细胞, 生物材料, 牙周组织再生, 组织工程

Abstract:

The ultimate treatment goal of periodontitis is the structural and functional regeneration of periodontium. However, existing methods for periodontal regeneration have difficulties in regenerating the hierarchical structure. Therefore, stem cell-based tissue engineering has attracted more and more attention for its advantages of self-renewal and multi-lineage differentiation potential. This review summarized the progress of research on periodontal tissue regeneration by combined biomaterials of dental-derived stem cells. It is pointed out that the application of autologous stem cell transplantation is limited by the donor source, and the subsequent research should focus on the development of multi-phase scaffold materials and the attempt to establish a stem cell bank.

Key words: mesenchymal stem cell, biomaterial, periodontal tissue regeneration, tissue engineering

中图分类号:

R781.4

王一玉, 黄佳萍, 丁佩惠, 董研. 联合生物材料的牙源性间充质干细胞进行牙周组织再生的研究进展[J]. 口腔医学, 2023, 43(3): 261-266.

WANG Yiyu, HUANG Jiaping, DING Peihui, DONG Yan. Research progress of periodontal tissue regeneration by combined biomaterials of dental derived mesenchymal stem cells[J]. Stomatology, 2023, 43(3): 261-266.

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