5-羟色胺与口腔扁平苔藓的相关性研究进展

doi:10.13591/j.cnki.kqyx.2023.04.013

摘要/Abstract

摘要：

口腔扁平苔藓(oral lichen planus,OLP)是一种慢性炎症性黏膜病,已有文献表明精神因素是其重要的致病因素之一。同时,OLP又是一种免疫失调引起的自身免疫性疾病,笔者怀疑精神因素可能通过某些因子作用于局部免疫,引起免疫失调,从而在OLP的发病机制中发挥作用。5-羟色胺(5-hydroxytryptamine,5-HT)是一种单胺类神经递质,可作为神经系统和免疫系统双边接触的介质。5-HT可能通过与多种受体结合,激活不同信号通路,对情绪调节以及免疫细胞的增殖、迁移、凋亡等过程均起到重要的调节作用。近年来的研究表明5-HT可能参与OLP的发生、发展过程。该文针对5-HT及其受体的功能、它们在自身免疫性疾病中的特异性表达以及在OLP中可能发挥的作用作一综述。

关键词: 5-羟色胺, 口腔扁平苔藓, 精神因素, 免疫因素

Abstract:

Oral lichen planus (OLP) is a chronic inflammatory mucosal disease. The existing literature shows that psychological factors are one of the important pathogenic factors. At the same time, OLP is an autoimmune disease caused by immune dysregulation. We suspect that psychological factors may cause immune dysregulation through the chemical reaction of some factors and local immunity in the pathogenesis of OLP. 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter, which can be used as a mediator of bilateral contact between the nervous system and the immune system. 5-HT may activate different signaling pathways through binding with multiple receptors, and it plays an important role in regulating emotion regulation and the proliferation, migration and apoptosis of immune cells. Recent studies have shown that 5-HT may be involved in the occurrence and development of OLP. This paper will review the function of 5-HT and its receptors, their specific expression in autoimmune diseases and their possible roles in OLP.

Key words: 5-hydroxytryptamine, oral lichen planus, psychological factor, immune factor

中图分类号:

R781.59

王谦,张冬青,张松蔚,詹渊博,穆森. 5-羟色胺与口腔扁平苔藓的相关性研究进展[J]. 口腔医学, 2023, 43(4): 353-358.

WANG Qian,ZHANG Dongqing,ZHANG Songwei,ZHAN Yuanbo,MU Sen. Research progress of the correlation between 5-hydroxytryptamine and oral lichen planus[J]. Stomatology, 2023, 43(4): 353-358.

图/表 1

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免疫细胞	受体类型	主要功能
T淋巴细胞	5-HT_1A	T细胞增殖
	5-HT_1B
	5-HT₃
	5-HT_2A	T细胞活化
	5-HT₇	T细胞活化
树突状细胞(未成熟)	5-HT_1B	趋化作用,调节细胞内Ca²⁺浓度
	5-HT_1E
	5-HT_2A
	5-HT_2B
树突状细胞(成熟)	5-HT₄	影响细胞因子分泌
树突状细胞(成熟)	5-HT₇	影响细胞因子分泌
肥大细胞	5-HT_1A	趋化作用
巨噬细胞	5-HT_1A	上调活性
单核细胞	5-HT_1A	抑制H₂O₂的释放,促进炎症