5-羟色胺与口腔扁平苔藓的相关性研究进展

doi:10.13591/j.cnki.kqyx.2023.04.013

摘要/Abstract

摘要：

口腔扁平苔藓(oral lichen planus,OLP)是一种慢性炎症性黏膜病,已有文献表明精神因素是其重要的致病因素之一。同时,OLP又是一种免疫失调引起的自身免疫性疾病,笔者怀疑精神因素可能通过某些因子作用于局部免疫,引起免疫失调,从而在OLP的发病机制中发挥作用。5-羟色胺(5-hydroxytryptamine,5-HT)是一种单胺类神经递质,可作为神经系统和免疫系统双边接触的介质。5-HT可能通过与多种受体结合,激活不同信号通路,对情绪调节以及免疫细胞的增殖、迁移、凋亡等过程均起到重要的调节作用。近年来的研究表明5-HT可能参与OLP的发生、发展过程。该文针对5-HT及其受体的功能、它们在自身免疫性疾病中的特异性表达以及在OLP中可能发挥的作用作一综述。

关键词: 5-羟色胺, 口腔扁平苔藓, 精神因素, 免疫因素

Abstract:

Oral lichen planus (OLP) is a chronic inflammatory mucosal disease. The existing literature shows that psychological factors are one of the important pathogenic factors. At the same time, OLP is an autoimmune disease caused by immune dysregulation. We suspect that psychological factors may cause immune dysregulation through the chemical reaction of some factors and local immunity in the pathogenesis of OLP. 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter, which can be used as a mediator of bilateral contact between the nervous system and the immune system. 5-HT may activate different signaling pathways through binding with multiple receptors, and it plays an important role in regulating emotion regulation and the proliferation, migration and apoptosis of immune cells. Recent studies have shown that 5-HT may be involved in the occurrence and development of OLP. This paper will review the function of 5-HT and its receptors, their specific expression in autoimmune diseases and their possible roles in OLP.

Key words: 5-hydroxytryptamine, oral lichen planus, psychological factor, immune factor

中图分类号:

R781.59

王谦,张冬青,张松蔚,詹渊博,穆森. 5-羟色胺与口腔扁平苔藓的相关性研究进展[J]. 口腔医学, 2023, 43(4): 353-358.

WANG Qian,ZHANG Dongqing,ZHANG Songwei,ZHAN Yuanbo,MU Sen. Research progress of the correlation between 5-hydroxytryptamine and oral lichen planus[J]. Stomatology, 2023, 43(4): 353-358.

图/表 1

参考文献 52

[1]	Manczyk B, Gołda J, Biniak A, et al. Evaluation of depression, anxiety and stress levels in patients with oral lichen planus[J]. J Oral Sci, 2019, 61(3):391-397. doi: 10.2334/josnusd.18-0113 pmid: 31178457
[2]	Sivolap YP, Damulin IV. Stroke and depression[J]. Zh Nevrol Psikhiatr Im S S Korsakova, 2019, 119(9):143-147.
[3]	Huang JG, Li GM, Xiang JH, et al. Immunohistochemical study of serotonin in lesions of psoriasis[J]. Int J Dermatol, 2004, 43(6):408-411. pmid: 15186219
[4]	Huang JG, Li GM, Xiang JH, et al. Immunohistochemical study of serotonin in lesions of chronic eczema[J]. Int J Dermatol, 2004, 43(10):723-726. pmid: 15485527
[5]	张梅华, 缪羽, 昭日格图. 口腔扁平苔藓疾病与心理人格生活质量之间的关系[J]. 实用口腔医学杂志, 2019, 35(3):436-438.
[6]	Zhan YB, Zhou S, Li Y, et al. Using the BITOLA system to identify candidate molecules in the interaction between oral lichen planus and depression[J]. Behav Brain Res, 2017, 320: 136-142. doi: S0166-4328(16)31157-3 pmid: 27913255
[7]	Liao HL, Luo YX, Long L, et al. Anxiety and oral lichen planus[J]. Oral Dis, 2021, 27(3):506-514. doi: 10.1111/odi.v27.3
[8]	刘伟东, 赵民. 加味逍遥丸治疗口腔扁平苔藓伴焦虑抑郁状态患者的疗效评价[J]. 上海口腔医学, 2019, 28(3):312-316.
[9]	Okaty BW, Commons KG, Dymecki SM. Embracing diversity in the 5-HT neuronal system[J]. Nat Rev Neurosci, 2019, 20(7):397-424. doi: 10.1038/s41583-019-0151-3 pmid: 30948838
[10]	John Jayakumar J, Panicker MM. The roles of serotonin in cell adhesion and migration, and cytoskeletal remodeling[J]. Cell Adh Migr, 2021, 15(1):261-271. doi: 10.1080/19336918.2021.1963574
[11]	Göthert M, Bönisch H, Malinowska B, et al. Serotonin discovery and stepwise disclosure of 5-HT receptor complexity over four decades. Part Ⅱ. Some contributions of Manfred Göthert[J]. Pharmacol Rep, 2020, 72(2):271-284. doi: 10.1007/s43440-019-00047-4 pmid: 32048263
[12]	di Giovanni G. Serotonin in health and disease[J]. Int J Mol Sci, 2020, 21(10):3500. doi: 10.3390/ijms21103500
[13]	Bacqué-Cazenave J, Bharatiya R, Barrière G, et al. Serotonin in animal cognition and behavior[J]. Int J Mol Sci, 2020, 21(5):1649. doi: 10.3390/ijms21051649
[14]	Chakraborty S, Lennon JC, Malkaram SA, et al. Serotonergic system, cognition, and BPSD in Alzheimer's disease[J]. Neurosci Lett, 2019, 704: 36-44. doi: S0304-3940(19)30214-9 pmid: 30946928
[15]	Troubat R, Barone P, Leman S, et al. Neuroinflammation and depression: A review[J]. Eur J Neurosci, 2021, 53(1):151-171. doi: 10.1111/ejn.v53.1
[16]	Schoenichen C, Bode C, Duerschmied D. Role of platelet serotonin in innate immune cell recruitment[J]. Front Biosci (Landmark Ed), 2019, 24(3):514-526. doi: 10.2741/4732 pmid: 30468670
[17]	le Mestre J, Duparc C, Reznik Y, et al. Illicit upregulation of serotonin signaling pathway in adrenals of patients with high plasma or intra-adrenal ACTH levels[J]. J Clin Endocrinol Metab, 2019, 104(11):4967-4980. doi: 10.1210/jc.2019-00425 pmid: 31074783
[18]	Pergolizzi S, Rizzo G, Favaloro A, et al. Expression of VAChT and 5-HT in ulcerative colitis dendritic cells[J]. Acta Histochem, 2021, 123(4):151715.
[19]	Cai MX, Zhou LL, Liao J, et al. IFN-γ inhibits 5-HT-induced melanin biosynthesis via downregulation of 5-HT receptors in vivo/in vitro[J]. J Pharmacol Sci, 2019, 141(1):1-8. doi: 10.1016/j.jphs.2019.05.005
[20]	Nordlind K, Thorslund K, Lonne-Rahm S, et al. Expression of serotonergic receptors in psoriatic skin[J]. Arch Dermatol Res, 2006, 298(3):99-106. doi: 10.1007/s00403-006-0652-6
[21]	Thorslund K, Amatya B, Dufva AE, et al. The expression of serotonin transporter protein correlates with the severity of psoriasis and chronic stress[J]. Arch Dermatol Res, 2013, 305(2):99-104. doi: 10.1007/s00403-012-1303-8
[22]	Thorslund K, El-Nour H, Nordlind K. The serotonin transporter protein is expressed in psoriasis, where it may play a role in regulating apoptosis[J]. Arch Dermatol Res, 2009, 301(6):449-457. doi: 10.1007/s00403-009-0933-y
[23]	Lonne-Rahm SB, Rickberg H, El-Nour H, et al. Neuroimmune mechanisms in patients with atopic dermatitis during chronic stress[J]. J Eur Acad Dermatol Venereol, 2008, 22(1):11-18. doi: 10.1111/j.1468-3083.2007.02202.x pmid: 18181968
[24]	El-Nour H, Lundeberg L, Abdel-Magid N, et al. Serotonergic mechanisms in human allergic contact dermatitis[J]. Acta Derm Venereol, 2007, 87(5):390-396. doi: 10.2340/00015555-0288
[25]	Jørandli JW, Thorsvik S, Skovdahl HK, et al. The serotonin reuptake transporter is reduced in the epithelium of active Crohn's disease and ulcerative colitis[J]. Am J Physiol Gastrointest Liver Physiol, 2020, 319(6):G761-G768. doi: 10.1152/ajpgi.00244.2020
[26]	艾福帅, 雨桐, 李冠睿, 等. 口腔扁平苔藓的免疫因素研究进展[J]. 中国医学创新, 2021, 18(16):181-184.
[27]	Nosratzehi T. Orallichen planus: An overview of potential risk factors, biomarkers and treatments[J]. Asian Pac J Cancer Prev, 2018, 19(5):1161-1167.
[28]	Kurmuş GI, Gönül M, Canpolat F, et al. Serotonin expression in lichen planus lesions and its relationship with depression/anxiety[J]. Ann Dermatol, 2019, 31(2):146-153. doi: 10.5021/ad.2019.31.2.146
[29]	Quah SKL, McIver L, Roberts AC, et al. Trait anxiety mediated by amygdala serotonin transporter in the common marmoset[J]. J Neurosci, 2020, 40(24):4739-4749. doi: 10.1523/JNEUROSCI.2930-19.2020 pmid: 32393533
[30]	Chen L, Gong WK, Yang CP, et al. Pten is a key intrinsic factor regulating raphe 5-HT neuronal plasticity and depressive behaviors in mice[J]. Transl Psychiatry, 2021, 11(1):186. doi: 10.1038/s41398-021-01303-z
[31]	Qiao YJ, Zhao JB, Li C, et al. Effect of combined chronic predictable and unpredictable stress on depression-like symptoms in mice[J]. Ann Transl Med, 2020, 8(15):942. doi: 10.21037/atm-20-5168 pmid: 32953742
[32]	Lu QH, Mouri A, Yang Y, et al. Chronic unpredictable mild stress-induced behavioral changes are coupled with dopaminergic hyperfunction and serotonergic hypofunction in mouse models of depression[J]. Behav Brain Res, 2019, 372: 112053.
[33]	Kudryashov NV, Kalinina TS, Shimshirt AA, et al. The behavioral and neurochemical aspects of the interaction between antidepressants and unpredictable chronic mild stress[J]. Acta Naturae, 2020, 12(1):63-72. doi: 10.32607/actanaturae.10942 pmid: 32477600
[34]	Li HW, Wang P, Huang LQ, et al. Effects of regulating gut microbiota on the serotonin metabolism in the chronic unpredictable mild stress rat model[J]. Neurogastroenterol Motil, 2019, 31(10):e13677.
[35]	Li GJ, Yang J, Wang X, et al. Effects of EGCG on depression-related behavior and serotonin concentration in a rat model of chronic unpredictable mild stress[J]. Food Funct, 2020, 11(10):8780-8787. doi: 10.1039/D0FO00524J
[36]	Abdouh M, Albert PR, Drobetsky E, et al. 5-HT_1A-mediated promotion of mitogen-activated T and B cell survival and proliferation is associated with increased translocation of NF-kappaB to the nucleus[J]. Brain Behav Immun, 2004, 18(1):24-34. pmid: 14651944
[37]	Deng SS, Xu YJ, Wang XX, et al. Study on the role of salivary flora and NF-κB inflammatory signal pathway in oral lichen planus[J]. Inflammation, 2020, 43(3):994-1008. doi: 10.1007/s10753-020-01185-1 pmid: 32016629
[38]	Wu H, Herr D, MacIver NJ, et al. CD4 T cells differentially express cellular machinery for serotonin signaling, synthesis, and metabolism[J]. Int Immunopharmacol, 2020, 88: 106922.
[39]	Inoue M, Okazaki T, Kitazono T, et al. Regulation of antigen-specific CTL and Th1 cell activation through 5-Hydroxytryptamine 2A receptor[J]. Int Immunopharmacol, 2011, 11(1):67-73. doi: 10.1016/j.intimp.2010.10.007 pmid: 20971187
[40]	Wu H, Denna TH, Storkersen JN, et al. Beyond a neurotransmitter: The role of serotonin in inflammation and immunity[J]. Pharmacol Res, 2019, 140: 100-114. doi: S1043-6618(18)30301-3 pmid: 29953943
[41]	Idzko M, Panther E, Stratz C, et al. The serotoninergic receptors of human dendritic cells: Identification and coupling to cytokine release[J]. J Immunol, 2004, 172(10):6011-6019. pmid: 15128784
[42]	Müller T, Dürk T, Blumenthal B, et al. 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo[J]. PLoS One, 2009, 4(7):e6453. doi: 10.1371/journal.pone.0006453
[43]	Méndez-Enríquez E, Hallgren J. Mast cells and their progenitors in allergic asthma[J]. Front Immunol, 2019, 10: 821. doi: 10.3389/fimmu.2019.00821 pmid: 31191511
[44]	Wang GD, Wang XY, Zou F, et al. Mast cell expression of the serotonin1A receptor in Guinea pig and human intestine[J]. Am J Physiol Gastrointest Liver Physiol, 2013, 304(10):G855-G863. doi: 10.1152/ajpgi.00421.2012
[45]	Martins LCA, Rocha NP, Torres KCL, et al. Disease-specific expression of the serotonin-receptor 5-HT(2C) in natural killer cells in Alzheimer's dementia[J]. J Neuroimmunol, 2012, 251(1/2):73-79. doi: 10.1016/j.jneuroim.2012.06.003
[46]	Hellstrand K, Hermodsson S. Serotonergic 5-HT1A receptors regulate a cell contact-mediated interaction between natural killer cells and monocytes[J]. Scand J Immunol, 1993, 37(1):7-18. pmid: 7678181
[47]	陶小安, 程斌. 口腔扁平苔藓治疗现状分析[J]. 口腔疾病防治, 2018, 26(3):143-150.
[48]	李珊珊, 柏平, 吴迎, 等. 钙调磷酸酶/活化T细胞因子信号通路在有氧运动诱导高血压大鼠血管平滑肌细胞K_V2.1通道表达上调中的作用[J]. 中国动脉硬化杂志, 2018, 26(8):767-773.
[49]	Homma K, Kitamura Y, Ogawa H, et al. Serotonin induces the increase in intracellular Ca²⁺ that enhances neurite outgrowth in PC12 cells via activation of 5-HT3 receptors and voltage-gated calcium channels[J]. J Neurosci Res, 2006, 84(2):316-325. doi: 10.1002/(ISSN)1097-4547
[50]	Zulkifli MH, Viswenaden P, Jasamai M, et al. Potential roles of 5-HT 3 receptor (5-HT 3 R) antagonists in modulating the effects of nicotine[J]. Biomed Pharmacother, 2019, 112: 108630.
[51]	Turner JH, Garnovskaya MN, Raymond JR. Serotonin 5-HT_1A receptor stimulates c-Jun N-terminal kinase and induces apoptosis in Chinese hamster ovary fibroblasts[J]. Biochim Biophys Acta, 2007, 1773(3):391-399.
[52]	Mo CL, Shetti D, Wei K. Erianin inhibits proliferation and induces apoptosis of HaCaT cells via ROS-mediated JNK/c-Jun and AKT/mTOR signaling pathways[J]. Molecules, 2019, 24(15):2727. doi: 10.3390/molecules24152727

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免疫细胞	受体类型	主要功能
T淋巴细胞	5-HT_1A	T细胞增殖
	5-HT_1B
	5-HT₃
	5-HT_2A	T细胞活化
	5-HT₇	T细胞活化
树突状细胞(未成熟)	5-HT_1B	趋化作用,调节细胞内Ca²⁺浓度
	5-HT_1E
	5-HT_2A
	5-HT_2B
树突状细胞(成熟)	5-HT₄	影响细胞因子分泌
树突状细胞(成熟)	5-HT₇	影响细胞因子分泌
肥大细胞	5-HT_1A	趋化作用
巨噬细胞	5-HT_1A	上调活性
单核细胞	5-HT_1A	抑制H₂O₂的释放,促进炎症