Abstract: Objective　To investigate the histocompatibility of Zr-Cu-Al-Ag amorphous alloy for dental restoration. Methods　According to the YY/T0279-1995, YY/T0127.8-2001, the sample were prepared and tested with the oral mucous membrane irritation test and subcutaneous implant test. Results　The result of oral mucous membrane irritation test showed that all samples did not have local or systemic adverse reactions and the histopathological findings were also normal, and the stimulus index in histologic evaluation is 0; the subcutaneous implant test displayed that the Zr-Cu-Al-Ag alloy had no apparent toxicity. One week after specimens were implanted , local tissue was found to be slightly red and swollen, and the biopsies showed a few inflammatory cells; 4-12 weeks later, it showed the inflammatory response gradually reduced as time prolonged, and the formation process of fiber coated from loose to tight. Conclusions　These data indicated that there is a good histocompatibility between Zr-Cu-AL-Ag alloy material and oral mucosa, skin and subcutaneous tissue.

Key words: Zr-based bulk metallic glasses, histocompatibility, biomedical material, New Zealand white rabbits