基质细胞衍生因子和甲状旁腺激素在组织再生中的作用

Abstract

Abstract: Chemokines are the most promising chemotactic agents of in situ tissue engineering. As one of the most important chemokines, stromal cell derived factor-1(SDF-1) can facilitate the chemotaxis and migration of stem cells expressing C-X-C chemokine receptor type4 (CXCR4) to the site of injury to promote tissue regeneration. Approved by the U. S. Food and Drug Administration (FDA), parathyroid hormone (PTH) is the unique bone anabolic drug for the treatment of osteoporosis, which can mobilize stem cells from bone marrow into circulation and prevent the proteolytic cleavage of SDF-1 by inhibiting the specific protease dipeptidyl peptidase-IV (DPP-IV). The dual effect of pushing and pulling on stem cells mediated by the combination of PTH and SDF-1 can recruit and home stem cells to promote tissue regeneration. This article made a brief review on the effects of SDF-1 and PTH on tissue regeneration.

Key words: PTH , SDF-1/CXCR4 , DPP-IV/CD26 , tissue regeneration

References

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The effects of stromal cell derived factor-1 and parathyroid hormone on tissue regeneration

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