Abstract: Objective To investigate the clinical efficacy of CGF(concentrate growth factors)on bone formation and repairation in the treatment of patients suffered from alveolar bone insufficiency. Methods Seventy-six patients aged between 17 and 63, including 45 males and 31 females, who had fovea bone defect of upper incisor or atrophic posterior maxilla and were treated in our clinical department from Jul. 2012 to Oct. 2014, were treated with lateral window sinus floor elevation, immediate implant combined with the application of CGF, or transcrestal sinus floor elevation. Patients who needed Guided Bone Regeneration (GBR) were separated into two groups. ①CGF therapy only; ②CGF combined with bone substitute or autograft. Regular re-examinations were taken 1 week, 1 month, 3 months, 6 months and 12 months after surgery and the patients were checked every 6 months in two years after operation. The characteristics of the healing of the wound, periodontal condition, implants mobility and the patients’ assessment of aesthetic and function of the prosthesis were recorded. Digital radiograph and cone beam computerized tomography(CBCT) were taken to observe the bone regeneration. Results By 22 months’ (6~34 months) follow-up observation on the average, one implant loosed after 6 weeks due to the wound dehiscence, while the rest had good osseointegration discovered by CBCT. The postoperative reaction of GBR applied with CGF was relieved and the success rate was 98.68%. Conclusion CGF can promote wound healing, enhance bone formation and osteointegration and the time of these procedures can also be reduced. CGF can be applied in the implant surgical operation since it is reliable, economical and safe.

Key words: Concentrate Growth Factors , Guided Bone Regeneration, Implant