环状RNA的研究进展

Abstract

Abstract: Abstract: Covalently closed circular RNAs (circRNAs) are mainly produced by precursor mRNAback-splicing of the 3 'and 5' ends of exons of thousands of genes in eukaryotes, which is a special class of noncoding RNA different from most linear RNAs.Because of its special structure, circRNAs are highly conserved and stable.These features give circRNAs many potential functions, such as miRNA sponges or binding RNA-related proteins to form an RNA-Protein complex that regulates gene transcription.The high stability, high abundance and tissue specific expression patterns of circRNAs have aroused extensive interest among researchers.In this review, we survey the recent progress on circRNAsbiogenesis, characteristics,formation, classification, main functions and potential implications in various diseases.

Key words: circRNAs, noncoding RNA, microRNA sponge, alternative splicing, diseases

CLC Number:

References

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Recent advances on the study of circular RNA

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