Abstract: Objective To evaluate the efficacy and safety of ornidazole in the treatment of pericoronitis of wisdom teeth by metaanalysis. Methods RCTs of ornidazole in the treatment of pericoronitis of wisdom teeth from the major databases (PubMed, Cochrane Library, CNKI, VIP, Wanfang) were searched from the basebuilding to December 2017. Metaanalysis was performed using Review Manager 5.3 software after data extraction and evaluation. Results A total of 27 RCTs were included, including 3 464 patients. Metaanalysis showed that ornidazole could improve the efficiency, reduce duration time of pain and pericardial swelling, also inhibit oral bacterial density, and had less adverse reactions. Conclusion Olanzanide has a significant effect on the treatment of periapical periodontitis and has less adverse reactions, which is worthy to be popularized in clinic.

Key words: ornidazole, pericoronitis, meta-analysis