高熵合金AlFeCoCuTiNbx的体外血液相容性评价

Abstract

Abstract: Objective　To evaluate the blood compatibility of a new high entropy alloy AlFeCoCuTiNbx. Methods The hemocompatibility of the materials was tested by means of hemolysis test, dynamic coagulation test, anticoagulant time measurement and platelet adhesion test. Results AlFeCoCuTiNbx (X=0.4,0.5) alloy had the best blood compatibility, and the hemolysis rate of all samples was less than 0.5%. In the anticoagulant properties, the dynamic coagulation time and the prothrombin time Nb0.4 and Nb0.5 were nearly to the time of pure Ti, and Ti6Al4V, and were relatively prolonged compared with the other experimental groups, however there was no significant difference in PT test. Platelet adhesion experiments showed that Nb0.4, Nb0.5 had less platelet adhesion, agglomeration and pseudo-foot extension. Conclusion The high entropy alloy AlFeCoCuTiNbx (X=0.4, 0.5) has good blood compatibility ,which might have some certain application prospects in the medical field.

Key words: Key words：High-entropy alloy, Blood compatibility, Biocompatibility, Metal materials

CLC Number:

R783.1

References 20

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In vitro blood compatibility evaluation of high entropy alloy AlFeCoCuTiNbx

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