单细胞测序研究进展及其在口腔医学中的应用

Abstract

Abstract: Single-cell sequencing refers to the detection, identification and analysis of cell components especially genetic materials at the single-cell level, which can reach single-molecule resolution. Single-cell sequencing captures and analyzes the information about genome, epigenome (including DNA methylation, chromosome accessibility and chromatin topology, etc.), transcriptome as well as cell topological space to define the cell types and further study cellular function, cell lineage, cell migration and transformation as well as cell the molecular effects on cell fate determination and so on. In recent years, to improve the noise-limited effectiveness of single-cell sequencing and research the interrelationship between different omics, single-cell sequencing has developed from single-omics to multi-omics and has been widely used in many fields of life science such as molecular biology, developmental biology, neuroscience, tumor research and immunology, providing powerful technical support for life science research.

Key words: single cell sequencing, multi-omics single cell sequencing, life science research

CLC Number:

R446.7

References 85

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Research progress of single cell sequencing and its application in stomatology

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