Abstract: The dental implant inserted into the alveolar bone initially triggers the foreign body reaction and then turns to healing process, which is primarily mediated by macrophages. Recently, most studies about macrophages have discovered that regulating macrophages can promote the wound healing of soft and hard tissues around the implant. However, the specific roles and mechanism of macrophages during this process are rarely reported. In this article, the related studies trying to reveal the effect and mechanisms of macrophages during the healing process of peri-implant were reviewed.

Key words: dental implant surgery, macrophage polarization, wound healing, osteointegration, peri-implant disease