Abstract: Objective　To analyze the clinical and histological results of regenerative endodontic procedures of immature permanent teeth and to evaluate the healing outcomes of regenerative treatment for immature permanent teeth. Methods　MEDLINE and Web of Science databases were used to search and analyze the literatures with histological results of regenerative endodontic procedures of human immature permanent teeth before December 31, 2019. Results　Sixteen literatures were included, all of which were case reports, including 25 teeth. Of the 25 included teeth, 2 failed, 2 reached the primary-goal, 16 reached the secondary goal, and 5 reached the tertiary goal in clinical evaluation. Histological evaluation to 21 teeth reaching secondary goal and tertiary goal, among 19 teeth receiving hard tissue histological examination, only 2 teeth of found typical of dentine structure, and 17 teeth found bone-like, cementum-like or tertiary dentin-like tissue. Among 20 teeth receiving soft tissue histological examination, only 3 teeth found typical odontoblast-like cells. In immunohistochemistry examination of 10 teeth, 5 teeth found nerve regeneration. Conclusions　Immature permanent teeth could achieve the success of clinical examination after regenerative endodontic procedures, but the continued development of the root was the deposition of dentin-like, bone-like and cement-like tissues in the root canal wall, the regain of pulp vitality was due to nerve regeneration.

Key words: Regenerative endodontic procedures, ?immature?permanent?teeth, clinical symptoms, histology, descriptive systematic review