Abstract: Photobiomodulation (PBM) therapy is the application of light to stimulate cell responses aimed at alleviating pain, reducing inflammation, and promoting tissue regeneration. In recent years, a large number of basic experiments have found that PBM can regulate the inflammatory process and slow down the pain response. Several clinical trials have also proved the efficiency of PBM in temporomandibular disorders (TMD). This article aims to present a contemporary and comprehensive review on the role of PBM therapy in the treatment of TMD.