›› 2021, Vol. 41 ›› Issue (3): 284-288.

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Research progress of adiponectin in bone metabolism

  

  • Received:2020-05-27 Revised:2020-07-03 Online:2021-03-28 Published:2021-03-28

Abstract: Adiponectin (APN) is an endogenous cytokine secreted by adipose tissue. After binding to the receptor, it participates in the body's metabolic regulation. Therefore, adiponectin and adiponectin receptors have also become important molecular targets for the treatment of metabolic diseases. The research of adiponectin signal transduction has a positive effect on guiding the clinical treatment of bone metabolism related diseases. This article reviews the biological characteristics of adiponectin, its signal transduction, and the effects of adiponectin on bone metabolism to provide a reference for the treatment of adiponectin in bone metabolic diseases.

Key words: Adiponectin, Adiponectin receptor, Adipokine, Osteoanabolic

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