Abstract: Objective To study the physicochemical properties and cytobiological characteristics of pure titanium coated with polydopamine-baicalin composite coating. Methods Pure titanium was coated with polydopamine-baicalin composite coating by co-deposition. Titanium plates were divided into pure titanium group, baicalin group, polydopamine group and polydopamine baicalin group (experimental group). The surface morphology and element distribution were analyzed. Rat bone marrow mesenchymal stem cells (BMSCs) were cultured on the surface of titanium plates in each group, and the proliferation of BMSCs was detected to explore the effect on osteogenic differentiation. Results The polydopamine-baicalin composite coating was loaded on the surface of pure titanium by co-deposition method, and the hydrophilicity was enhanced, which had good cell proliferation and adhesion; the alkaline phosphatase (ALP) level of the experimental group was higher than that of the control group at 7 and 14 days of culture (P＜0.05). Conclusion The polydopamine-baicalin composite coating prepared by co-deposition method on pure titanium has good biocompatibility and can promote the osteogenic differentiation of BMSCs.

Key words: pure titanium, polydopamine, baicalin, co-deposition, BMSCs