唾液腺紧密连接蛋白Claudin的研究进展

doi:10.13591/j.cnki.kqyx.2023.02.015

摘要/Abstract

摘要：

紧密连接(tight junction,TJ)是参与旁细胞分泌途径中蛋白质相互作用的复杂动态系统,具有屏障功能和栅栏功能。Claudin家族构成紧密连接链的主干,在唾液腺放射性损伤、炎症性疾病、舍格伦综合征和糖尿病等病理状况下会出现表达模式的异常改变,导致紧密连接结构和功能异常,间接表现为唾液腺功能障碍。此外,唾液腺肿瘤中Claudin蛋白的表达差异也可作为判断肿瘤类型及预后的指标。本文重点综述了唾液腺常见Claudin蛋白的研究进展,包括结构、功能、相关疾病的表达模式及其应用,为Claudin蛋白相关疾病的临床研究和基础研究提供新思路。

关键词: 紧密连接, Claudin, 唾液腺, 表达模式, 异常改变

Abstract:

Tight junction(TJ) is complex dynamic system involved in protein interactions in the paracellular secretory pathway, with both barrier and fence functions. Claudin family, the main section of tight junction strands, will be abnormal in expression pattern in the circumstances of radiation injuries, inflammation, Sj?gren's syndrome, diabetes and other pathological conditions in salivary glands. This change leads to abnormal structure and function of tight junctions, indirectly manifested as salivary gland dysfunction. In addition, the difference of Claudin expression in salivary gland tumors can also be used as an indicator of tumor type and prognosis. This review focuses on the progress of research on common Claudin in salivary glands, including the structure, function, expression patterns of related diseases and their applications. It is believed that the review may provide new ideas for clinical and basic research on Claudin protein-related diseases.

Key words: tight junction, Claudin, salivary glands, expression pattern, abnormal change

中图分类号:

R781.7

张鹏鑫, 费润馨, 许辉. 唾液腺紧密连接蛋白Claudin的研究进展[J]. 口腔医学, 2023, 43(2): 176-181.

ZHANG Pengxin, FEI Runxin, XU Hui. Research progress of tight junction protein Claudin of salivary glands[J]. Stomatology, 2023, 43(2): 176-181.

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