啮齿类动物种植体周围炎模型构建的研究进展及应用

doi:10.13591/j.cnki.kqyx.2023.02.016

摘要/Abstract

摘要：

近年来,随着种植牙的普及,种植体周围炎的发生率也逐年升高,而对种植体周围炎的发病机制仍缺乏深入探究。动物模型是研究临床疾病发病机制的良好桥梁,小型猪、犬、非人类灵长类动物、啮齿类动物等均被用于构建种植体周围炎模型,其中啮齿类动物及其饲养条件易获得,研究应用广泛。本文就啮齿类动物种植体周围炎模型的构建方法、研究进展及应用进行综述。

关键词: 种植体周围炎, 动物模型, 建模方法, 模型应用

Abstract:

With the increasing popularity of dental implants, prevalence of peri-implantitishas also been increasing in recent years. However, a deeper understanding of the pathogenesis of peri-implantitis is still lacking. Animal models are a good bridge for studying the pathogenesis of clinical diseases. Animals such as mini-pigs, canines, non-human primates and rodents are used to construct animal models of peri-implantitis. Among them, rodents are easy to obtain and feed, and have a wide range of applications for research. In this review, we summarize the construction of rodent modelswithperi-implantitis as well as the research progress and applications.

Key words: peri-implantitis, animal model, modeling method, model application

中图分类号:

R782.1

戴雨薇, 李洁, 孙媛元, 吴轶群, 孟箭. 啮齿类动物种植体周围炎模型构建的研究进展及应用[J]. 口腔医学, 2023, 43(2): 182-187.

DAI Yuwei, LI Jie, SUN Yuanyuan, WU Yiqun, MENG Jian. Research progress and application of rodents model construction of peri-implantitis[J]. Stomatology, 2023, 43(2): 182-187.

图/表 2

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种类	干预方式	植入时间点(拔牙术后)	干预时间(植入术后)	处死时间点(干预后)
小鼠	结扎^{[16???????????-28]}	即刻/6~8周	4周	1~12周
	脂多糖^[29]	8周	4周	6周
	灌喂^[30-31]	即刻	3~6周	6周
大鼠	结扎^[32?-34]	3~4周	4周~38 d	4周
	脂多糖^[35]	即刻/4周	4~12周	4周
	灌喂^[36]	即刻/4周	9周	12周