牙本质敏感症治疗材料的研究进展

doi:10.13591/j.cnki.kqyx.2023.05.001

口腔医学 ›› 2023, Vol. 43 ›› Issue (5): 385-392.doi: 10.13591/j.cnki.kqyx.2023.05.001

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牙本质敏感症治疗材料的研究进展

陈诺,卫彦()

北京大学口腔医院特诊科,国家口腔生物材料与数字医疗器械工程研究中心,国家口腔医学总局口腔材料重点实验室,北京大学口腔医学院北京生物材料实验室,北京(100081)

修回日期:2023-01-01 出版日期:2023-05-28 发布日期:2023-05-31
通讯作者: 卫彦 E-mail:kqweiyan@bjmu.edu.cn
作者简介:专家介绍:卫彦, 北京大学口腔医学院主任医师、教授、博士研究生导师。致力于牙齿修复的基础理论、关键技术与临床策略研究,共发表SCI 论文72篇,以通信/第一作者在Science、 Nat. Mater.、 Nat. Comm.、 Adv.Mater.等期刊发表SCI 论文46篇,授权国际专利5 项、国内专利6项。主持12项国家及省部级项目,获杰青、优青、万人青拔、首届北京市杰出青年中关村奖、树兰医学青年奖、茅以升青年科技奖等;受邀担任科技部重点研究计划专项指南编制专家、国药局医疗器械技术评审委员会专家委员、国际牙医师学院Fellow等。
基金资助:
科技部国家重点研发计划(2020YFA0710401);国家自然科学基金国家杰出青年科学基金(82225012);首都临床特色诊疗技术研究及转化应用(Z221100007422088)

Progress in the treatment materials of dentin hypersensitivity

CHEN Nuo,WEI Yan()

Department of Geriatric Dentistry, Peking University School and Hospital of Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, NMPA Key Laboratory for Dental Materials, Beijing Laboratory of Biomedical Materials, Peking University School and Hospital of Stomatology, Beijing 100081, China

Revised:2023-01-01 Online:2023-05-28 Published:2023-05-31
Contact: WEI Yan E-mail:kqweiyan@bjmu.edu.cn

摘要/Abstract

摘要：

近年来,各类生物材料在牙齿脱敏的治疗中发挥重要作用,如直接堵塞牙本质小管的矿化材料、引导矿化堵塞牙本质小管的大分子材料、高分子/矿化物复合堵塞牙本质小管的材料、降低神经敏感性材料以及电荷材料等。本文将系统评述用于牙本质敏感症治疗的创新生物材料,首次将其按作用机制具体分类并重点关注电荷材料的治疗机制,提出牙本质敏感症的离子电流传导机制,并期待创新生物材料能够为探索口腔疾病的致病机制和治疗方法开拓新模式和新思路。

关键词: 生物材料, 牙本质敏感症, 口腔疾病治疗, 离子电流传导机制

Abstract:

Biomaterials have been the focus of research and innovation in medical materials in recent years. They are natural or synthetic materials that can contact and interact with human cells, tissues and organs to obtain diagnostic, restorative or therapeutic effects. In stomatology, biomaterials have received high attention, such as applications in implant restorations, pulp regeneration, periodontal tissue regeneration and other frontier fields. Dentine hypersensitivity is manifested as short and sharp pain from stimulus to exposed dentin, which has high prevalence and seriously affects people's daily life. However, the pathogenesis is still controversial and traditional treatment is ineffective. Recently, various biomaterials have been invented to treat dentine hypersensitivity. This paper reviews the innovative development of biomaterials in the treatment of dentine hypersensitivity and highlights the ionic mechanism. It is expected that biomaterials can provide new models and ideas for exploring the pathogenesis and therapies of oral diseases.

Key words: biomaterials, dentine hypersensitivity, oral diseases treatment, ionic mechanism

中图分类号:

R781.2

陈诺,卫彦. 牙本质敏感症治疗材料的研究进展[J]. 口腔医学, 2023, 43(5): 385-392.

CHEN Nuo,WEI Yan. Progress in the treatment materials of dentin hypersensitivity[J]. Stomatology, 2023, 43(5): 385-392.

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牙本质敏感症治疗材料的研究进展

Progress in the treatment materials of dentin hypersensitivity

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