肉芽肿性多血管炎临床表现及诊断新进展

doi:10.13591/j.cnki.kqyx.2024.03.009

口腔医学 ›› 2024, Vol. 44 ›› Issue (3): 209-213.doi: 10.13591/j.cnki.kqyx.2024.03.009

肉芽肿性多血管炎临床表现及诊断新进展

田欣,吴思华,但红霞,曾昕,王冏珂,陈谦明()

口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,口腔黏膜病国家临床重点专科,中国医学科学院口腔黏膜癌变与防治创新单元,四川大学华西口腔医学院黏膜病科,四川成都(610041)

收稿日期:2023-05-25 出版日期:2024-03-28 发布日期:2024-03-20
通讯作者: 陈谦明 E-mail:qmchen@zju.edu.cn
基金资助:
中国医学科学院医学与健康科技创新工程(2019-I2M-5-004);国家自然科学基金(81991502);国家自然科学基金(82201074)

New developments in the clinical presentation and diagnosis of granulomatosis with polyangiitis

TIAN Xin,WU Sihua,DAN Hongxia,ZENG Xin,WANG Jiongke,CHEN Qianming()

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & National Key Laboratory of Oral Mucosal Diseases & lnnovation Unit of Oral Mucosal Carcinogenesis and Prevention, Chinese Academy of Medical Sciences & Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

Received:2023-05-25 Online:2024-03-28 Published:2024-03-20

摘要/Abstract

摘要：

肉芽肿性多血管炎是一种系统性血管炎疾病,可累及口腔、眼、鼻、肺及肾脏等全身多个器官,发病率较低但死亡率较高,起病隐匿,早期症状容易与其他疾病混淆,其主要以肉芽肿和局灶性坏死的形成、血管的炎症为特征,临床多采用糖皮质激素及免疫抑制剂联合治疗。随着现代技术的发展以及对其临床表现认知的加深,肉芽肿性多血管炎的分类诊断标准被重新制定。该文主要从口腔角度对肉芽肿性多血管炎的临床表现、分类诊断标准及鉴别诊断进行更新,以期为临床工作提供一定的参考。

关键词: 肉芽肿性多血管炎, 自身免疫性疾病, 临床表现, 诊断, 鉴别诊断

Abstract:

Granulomatosis with polyangiitis is a systemic vasculitis disease, which can involve multiple organs of the whole body such as mouth, eyes, nose, lung and kidney. It has low incidence but a high mortality rate, hidden onset, and early symptoms are easily confused with other diseases. It is mainly characterized by the formation of granuloma, focal necrosis and vascular inflammation. The combination of glucocorticoid and immunosuppressant is usually used in clinical treatment. The diagnostic criteria of granulomatosis with polyangiitis has been reformulated with the development of modern technology and increased recognition of its clinical manifestations. Therefore, this paper mainly updated the clinical manifestations, classification diagnostic criteria and differential diagnosis of granulomatous polyvasculitis from the perspective of oral cavity, in order to provide reference for clinical work.

Key words: granulomatosis with polyangiitis, autoimmune disease, clinical presentation, diagnosis, differential diagnosis

中图分类号:

R543.7

田欣, 吴思华, 但红霞, 曾昕, 王冏珂, 陈谦明. 肉芽肿性多血管炎临床表现及诊断新进展[J]. 口腔医学, 2024, 44(3): 209-213.

TIAN Xin, WU Sihua, DAN Hongxia, ZENG Xin, WANG Jiongke, CHEN Qianming. New developments in the clinical presentation and diagnosis of granulomatosis with polyangiitis[J]. Stomatology, 2024, 44(3): 209-213.

图/表 3

参考文献 26

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肉芽肿性多血管炎临床表现及诊断新进展

New developments in the clinical presentation and diagnosis of granulomatosis with polyangiitis

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