关键词: 光动力疗法, 甘氨酸龈下喷砂, Ⅲ期牙周炎, 残留牙周袋

Abstract:

Objective To explore the efficacy and the impact on the periodontal microenvironment of photodynamic therapy (PDT) combined with subgingival glycine powder air polishing (SubGPAP) for patients with stage Ⅲ periodontitis on residual periodontal pockets. Methods Forty patients who visited the Department of Periodontology at our hospital with stage Ⅲ periodontitis were selected. After 4-6 weeks of initial treatment, the residual periodontal pockets of >4 mm depth with bleeding on probing, or ≥6 mm depth were randomly assigned in a split-mouth design, to receive subgingival scaling and root planning (SRP) (control group) or PDT+ SubGPAP + SRP (test group). Indicators including probing depth (PD), clinical attachment loss (CAL), bleeding index (BI), plaque index (PLI), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β) at baseline, 6 weeks and 3 months after treatment were measured and compared. Results The clinical indicators showed significant reductions in both groups at 6 weeks and 3 months compared with those at baseline (P<0.05). The TNF-α in test group showed no significant difference at 3 months compared with 6 weeks (P>0.05), while the other indicators in both groups showed significant reductions at 3 months compared with those at 6 weeks (P<0.05). The PD, CAL, BI, TNF-α, IL-6 and IL-1β in test group showed a significant reduction than those in the control group at 6 weeks and 3 months(P<0.05). The PLI in test group showed a significant reduction at 6 weeks (P<0.05). Conclusion PDT combined with SubGPAP assisted SRP for patients with stage Ⅲ periodontitis on residual periodontal pockets is conducive to enhancing the clinical efficacy and improving the microenvironment.

Key words: photodynamic therapy, subgingival glycine powder air polishing, stage Ⅲ periodontitis, residual periodontal pocket