环孢素治疗糜烂型口腔扁平苔藓的随机对照试验

›› 2013, Vol. 33 ›› Issue (10): 665-667.

环孢素治疗糜烂型口腔扁平苔藓的随机对照试验

孙玉亮,赵今,梁学萍,牛巧丽,努尔比亚

新疆医科大学第一附属医院

收稿日期:2012-12-31 修回日期:2013-03-24 出版日期:2013-10-28 发布日期:2013-10-31
通讯作者: 孙玉亮 E-mail:sunyuliang83@yahoo.cn
基金资助:
新疆医科大学第一附属医院科研专项基金青年专项

Cyclosporine for the treatment of erosive oral lichen planus:A Randomized controlled trial

Received:2012-12-31 Revised:2013-03-24 Online:2013-10-28 Published:2013-10-31

摘要/Abstract

摘要： [摘要] 目的比较环孢素和氟轻松治疗糜烂型口腔扁平苔藓的疗效和安全性。方法采用随机对照试验设计，将60例糜烂型口腔扁平苔藓患者随机分为两组（随机数字表法），每组各30例，分别给与环孢素（试验组）和氟轻松软膏（对照组）治疗6周，治疗结束后评价疗效和安全性，并于3个月后复查。结果治疗结束后评价疗效：试验组有效率93.3%,对照组96.7%，试验组视觉量表值(VAS)24.73± 15.65,对照组34.27±16.36。统计后两种药物在促进病损愈合方面疗效差异无统计学意义（X2=0.351, P＞0.05）,环孢素在减轻患者疼痛方面优于氟轻松（P＜0.05）。治疗过程中不良反应发生率环孢素比氟轻松要低一些。3个月后复查：试验组有效率96.7%,对照组80.0%.试验组VAS值26.63±17.01，对照组37.37±18.43。统计结果显示环孢素在缩小病损面积（X2=4.043, P＜0.05）、减轻疼痛方面（P＜0.05）均优于氟轻松。结论环孢素治疗糜烂型OLP比氟轻松有着更肯定的疗效和安全性，值得临床进一步推广应用。

关键词: 关键词：环孢素, 糜烂型口腔扁平苔藓, 随机对照试验, Key words: Cyclosporine, erosive Oral lichen planus, Randomized controlled trial

Abstract: [Abstracts] Objective To compare the efficacy and the safety of Cyclosporine with Fluocinolone acetonide for erosive oral lichen planus. Methods Randomized controlled trial design: A total of 60 erosive OLP patients were randomly divided into two groups(use random table),every group 30 patients,were given Cyclosporine(test group) and Fluocinolone acetonide ointment(control group) respectively for 6 weeks.The efficacy and safety were evaluated at the end of treatment. After 3 months make a review. Results Effective rate of test group was 93.3%, control group 96.7%. Visual Analogue Score of test group was 24.73± 15.65 ,control group 34.27±16.36.After treatment there were not signi?cantly different between two medicine to Promote lesion healing（X2=0.351, P＞0.05）. Cyclosporine was better than Fluocinolone acetonide in relieve pain（P＜0.05）.The incidence of adverse reaction of Cyclosporine was less than Fluocinolone acetonide during treatment process.The After 3 month: Effective rate of test group 96.7%, control group 80.0%. Test group VAS 26.63±17.01，control group37.37±18.43。 Cyclosporine was better than Fluocinolone acetonide in promote lesion healing（X2=4.043, P＜0.05） and relieve pain（P＜0.05）.Conclusion Cyclosporine has more positive efficacy and safety than Fluocinolone acetonide. Cyclosporine worthy of further clinical application.

孙玉亮赵今梁学萍牛巧丽努尔比亚. 环孢素治疗糜烂型口腔扁平苔藓的随机对照试验[J]. 口腔医学, 2013, 33(10): 665-667.

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