新辅助化疗对口腔鳞状细胞癌Survivin表达影响及意义

›› 2013, Vol. 33 ›› Issue (10): 683-685.

新辅助化疗对口腔鳞状细胞癌Survivin表达影响及意义

孙黎波¹,兰玉燕¹,肖金刚²,张力²,周航宇³

1. 泸州医学院附属口腔医院
2. 四川省泸州医学院附属口腔医院
3. 四川省泸州医学院附属口腔医院口腔颌面外科

收稿日期:2012-07-25 修回日期:2012-10-21 出版日期:2013-10-28 发布日期:2013-10-31
通讯作者: 孙黎波 E-mail:slb-324324@163.com

Efect of neoadjuvant chemotherapy on Survivin expression in Oral squamous cell carcinoma

Received:2012-07-25 Revised:2012-10-21 Online:2013-10-28 Published:2013-10-31

摘要/Abstract

摘要： 目的　研究新辅助化疗对口腔鳞状细胞癌组织组织中Survivn蛋白表达的影响。方法　选择18例活检病理确诊为口腔鳞癌的临床病例，予DFP方案行术前新辅助化疗2个疗程，分取新辅助化疗前、后肿瘤组织，另取唇裂修补术中切除的多余的唇组织为口腔正常组织对照组10例，共3组，进行免疫组化染色检测Survivin表达。结果　正常口腔组织、新辅助化疗前、后肿瘤组织Survivin阳性细胞表达率分别为（14.50±1.96）%、（57.78±3.39）%、（45.72±2.32）%，组间比较F=814.37，P<0.05。Survivin平均光密度值为12.75±1.13、77.90±12.64、47.17±15.08，组间比较F=90.98，P<0.05。结论　Survivin在DFP方案新辅助化疗后表达显著降低。

关键词: 口腔鳞状细胞癌, Survivin蛋白, 免疫组化, Oral squamous cell carcinoma, Survivin protein, Immunohistochemistry

Abstract: Objective　To investigate the effect of neoadjuvant chemotherapy on survivin expression in oral squamous cell carcinoma. Methods　A total of 18 biopsy confirmed cases of OSCC were included. DFP program (cisplatin, 5-fluorouracil, bleomycin) was adopted and two courses of neoadjuvant chemotherapy were performed before operation. Tumor tissue before and after neoadjuvant chemotherapy was got, and normal lip tissue needless in cheilorrhaphy cut off from 10 cases was regarded as control group of normal oral tissue. The expression of Survivin was analyzed in the three groups by immunohistochemistry. Results　The expression rates of survivn positive cells in normal oral mucosa, OSCC before neoadjuvant chemotherapy and OSCC after neoadjuvant chemotherapy were 14.50±1.96%, 57.78±3.39% and 45.72±2.32% respectively (P<0.05), with conparison among groups F=814.37，P<0.05. The average optical densities of Survivin in normal oral mucosa, OSCC before neoadjuvant chemotherapy and OSCC after neoadjuvant chemotherapy were 12.75±1.13, 77.90±12.64 and 47.17±15.08 respectively, with conparison among groups F=90.98，P<0.05. Conclusion　 The expression of Surviving decreases obviously after neoadjuvant chemotherapy (DFP program).

中图分类号:

R739.85

孙黎波兰玉燕肖金刚张力周航宇. 新辅助化疗对口腔鳞状细胞癌Survivin表达影响及意义[J]. 口腔医学, 2013, 33(10): 683-685.

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