关键词: 羟基磷灰石, 镁, 骨整合, 种植体, 骨质疏松, hydroxyapatite, magnesium, osseointegration, implants, osteoporosis

Abstract: Objective　Osteoporosis was characterized by reduced bone density and bone mass, which affected the stability of implants. The purpose of this study was to investigate the effects of magnesium-containing hydroxyapatite (MgHA) coating on implant fixation in ovariectomized (OVX) rats. Methods　Control group possessed hydroxyapatite (HA) coating prepared by sol-gel method, while the experimental group used coating of MgHA with 10 % Ca2+ replaced by Mg2+ prepared in the same way. 18 OVX rats were randomly divided into two groups; one group received a HA implant separately in the bilateral femoral telecentric end and the other group got MgHA implants. 12 weeks later, implants together with surrounding bone tissue were harvested for histomorphometry, Micro-CT evaluation, and biomechanical testing. Results　In MgHA group, bone-to-implant contact rate and bone area ratio were （52.57±4.73）%,（36.76±3.31）%, while those in HA group were （34.06±5.20）%,（27.26±2.92）%. The maximum push-out force and interfacial shear strength were (63.98±4.08)N, and (2.63±0.25)N/mm2 in MgHA group, while those in HA group were (41.44±7.07)N, (2.22±0.33)N/mm2. In addition, bone volume fraction, trabecular thickness, trabecular number, trabecular separation, connectivity density, and osseointegration rate in MgHA group were （24.5±6.1）%,（80.6±11.9）μm, （5.8±0.5）mm?1,（194.7±38.2）μm, （51.9±5.6）mm?3, （58.6±6.2）%, while those in HA group were （16.6±4.3）%,（68.4±10.3）μm、（5.2±0.6）mm?1、（220.8±30.6）μm、（44.1±4.5）mm?3、（45.1±3.8）%. All the differences were statistically significant (P<0.05) except trabecular separation. Conclusions　Magnesium element can improve biological performance of implants in osteoporosis bone.