骨形成蛋白诱导活性材料联合引导组织再生术治疗牙周骨下袋的临床研究

›› 2013, Vol. 33 ›› Issue (9): 601-603.

骨形成蛋白诱导活性材料联合引导组织再生术治疗牙周骨下袋的临床研究

梅幼敏¹,宦泓²,吴煜卓²,曹盈²,杨晓雪²,孙敬伟²,周艳²

1. 江苏省南通市口腔医院
2. 南通市口腔医院

收稿日期:2013-03-11 修回日期:2013-06-20 出版日期:2013-09-28 发布日期:2013-10-30
通讯作者: 梅幼敏 E-mail:amandanne@163.com
基金资助:
江苏省南通市社会计划资助项目

Clinical study of the combination of osteoinduction active meterial and guided tissue regeneration in the treatment of periodontal intrabonydefects

Received:2013-03-11 Revised:2013-06-20 Online:2013-09-28 Published:2013-10-30

摘要/Abstract

摘要： 摘要目的　评估骨形成蛋白诱导活性材料（osteoinduction active meterial，OAM）复合部分自体骨，联合引导组织再生术（guided tissue regeneration,GTR）在牙周骨下袋治疗中的临床疗效。方法　46例患者的50颗骨下袋缺损患牙随机应用OAM /自体骨/GTR（试验组）、自体骨/GTR（对照组）治疗, 分别记录术前，术后12周、24周患牙牙周探诊深度(periodontal probing depth，PPD) 、临床附着丧失(clinical attachment loss ，CAL) 、龈沟出血指数(sulcus bleeding index ，SBI)及牙槽骨高度（alveolar bone height，AH）。结果　两组患牙术后各项指标均比基线时明显改善, 试验组与对照组比较PPD和CAL显著减少(术后12周时P<0.05，术后24周时P<0.01)、而SBI降低无显著性(P>0.05)。CBCT显示，试验组、对照组骨缺损区均有新骨形成，试验组较对照组AH显著增加(P<0.05)。结论　OAM /自体骨/GTR是治疗牙周骨下袋较为理想的方法。

关键词: 骨形成蛋白, 骨诱导活性材料, 自体骨, 引导组织再生, 牙周骨下袋, BMP, OAM, autologous bone, GTR, periodontal intrabony defects

Abstract: Abstract: Objective: To evaluate the effects of the combination of OAM and GTR in the treatment of periodontal intrabonydefects. Methods: 46 patients(50 periodontal intrabonydefects)were randomized into two groups of treatment: group A- OAM /autologous bone /GTR (experimental group) and group B- autologous bone / GTR (control group) .The followings were recorded before the operation, 12 weeks and 24 weeks after the operation：periodontal probing depth (PPD)、clinical attachment loss(CAL)、 sulcus bleeding index(SBI) and alveolar bone height（AH）．The effects were analyzed statistically by SPSS12.0．Results: After the operation ,both of the indicators in the two groups were significantly improved than those on the baseline.PPD and CAL in group A were significantly lower than those in group B(P<0.05 at the 12th weeks ,P<0.01 at the 24th weeks)．No significant diference in SBI reduction was observed between group A and B (P>0.05)．CBCT showed that there was new bone formation in bone defect area in both groups, but AH in group A increased significantly compared with group B (P <0.05). Conclusions: The therapy of OAM / autologous bone / GTR is more effective than the autologous bone /GTR therapy in reducing PPD and CAL and alleviating periodontitis．It is concluded that OAM / autologous bone / GTR is the ideal way to treat periodontal intrabonydefects.

中图分类号:

R781.05

梅幼敏宦泓吴煜卓曹盈杨晓雪孙敬伟周艳. 骨形成蛋白诱导活性材料联合引导组织再生术治疗牙周骨下袋的临床研究[J]. 口腔医学, 2013, 33(9): 601-603.

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