关键词: 牙种植体, 微纳复合, TiO2纳米管, 仿生构建, dental implant, micro/nano, TiO2 nanotubes, biomimetic fabrication

Abstract: Objective The study investigated an effective method of fabricating a biomimetic micro/nano structure similar to natural alveolar bone on dental implant surfaces in order to improve dental implants’ biocompatibility, osteoinductivity, and to provide a new idea to enhance implant success rate clinically. Methods According to the sizes and features of micron-scale structure (haversian system) and nano-scale structure (collagenous fibril) in natural alveolar bones, a composite biomimetic structure, i.e. micro-pit interlaced self-assemble TiO2 nanotubes on the surfaces of dental Ti implants in vitro was developed by double acid treatment and constant potential anodization. Results This micro/nano surface can provide larger surface energy, preferable roughness and hydrophilicity as compared to smooth mechanical surface and micron-scale counterparts (P<0.01). Conclusion This bioinspired micro/nano fabrication on dental implants’ surfaces brings about good performance for implants, and is more preferable for osseointegration of implants, so as to provide a new strategy for improving implant success rate. It reduces risk, and is safe, reliable, economical, practical. It can obtain good results, so it's suitable for further clinical research and promotion.