扁平苔藓中炎症与肿瘤相互关系的研究现状

›› 2014, Vol. 34 ›› Issue (11): 867-869.

扁平苔藓中炎症与肿瘤相互关系的研究现状

彭晖

安徽医科大学附属省立医院

收稿日期:2013-08-19 修回日期:2013-11-08 出版日期:2014-11-28 发布日期:2014-12-03
通讯作者: 彭晖 E-mail:penghui50537@sina.cn

Hui PENG

Received:2013-08-19 Revised:2013-11-08 Online:2014-11-28 Published:2014-12-03
Contact: Hui PENG E-mail:penghui50537@sina.cn

摘要/Abstract

摘要： 炎症与肿瘤之间关系密切，许多肿瘤起源于感染和慢性炎症。在炎症微环境和肿瘤微环境中大量炎性细胞和炎性因子的聚集，尤其是活性氧和活性氮的产生积聚能够改变细胞的正常内环境，引起原癌基因活化和抑癌基因灭活后启动肿瘤。口腔扁平苔癣作为潜在恶性病变，其癌变机制尚不十分明确，但局部的炎症微环境可能在其癌变过程中起着重要作用。

关键词: 炎症, 肿瘤, 口腔扁平苔藓, 癌变

Abstract: There is a close relationship between inflammation and tumor.Many tumor originated from infection and chronic inflammation.In the state of inflammatory and tumor microenvironment,inflammatory mediators,especially reactive oxygen and nitrogen species will change the cell's normal environment and lead to activation of oncogene and inactivation of tumor-suppressor gene,ultimately lead to the occurrence of tumor. Oral lichen planus is a kind of potential malignant lesions. The mechanism of carcinogenesis of OLP is still not very clear, but the local inflammatory microenvironment may play an important role in the occurrence and process of the tumor.

Key words: Inflammation, tumor, oral lichen planus, carcinogenesis

中图分类号:

R781.5/R73

彭晖. 扁平苔藓中炎症与肿瘤相互关系的研究现状[J]. 口腔医学, 2014, 34(11): 867-869.

Hui PENG. [J]. Stomatology, 2014, 34(11): 867-869.

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