掺镁羟基磷灰石涂层对种植体骨结合的影响

›› 2014, Vol. 34 ›› Issue (4): 249-249.

掺镁羟基磷灰石涂层对种植体骨结合的影响

史月华¹,谷志远¹,郑园娜²,何福明³,谷子芽⁴

1. 浙江中医药大学
2. 浙江省中医药大学口腔医学院
3. 浙江大学医学院附属口腔医院
4. 杭州口腔医院

收稿日期:2013-10-15 修回日期:2013-12-11 出版日期:2014-04-28 发布日期:2014-05-15
通讯作者: 史月华 E-mail:xsyh912@126.com
基金资助:
浙江省自然科学基金杰青项目

Effects of magnesium ?ubstituted hydroxyapatite coating on implant osseointegration

Received:2013-10-15 Revised:2013-12-11 Online:2014-04-28 Published:2014-05-15
Contact: Yue-Hua SHI E-mail:xsyh912@126.com
Supported by:
the Excellent Youth Science Foundation of Zhejiang Provincial Natural Science Foundation

摘要/Abstract

摘要： ［摘要］目的用荧光显微镜分析掺镁羟基磷灰石涂层对种植体骨结合的影响。方法将20个种植体分为2组，每组10个。一组为掺镁羟基磷灰石（magnesium-substituted hydroxyapatite,Mg-HA）涂层种植体；一组为纯羟基磷灰石（hydroxyapatite,HA）涂层种植体。涂层均采用电化学沉积技术制备。种植体植入成年兔股骨内。在种植术后第7天给予盐酸土霉素；在术后第28天给予茜素氨羧络合剂；在术后第46天给予钙黄绿素。8周后取出股骨，制备硬组织切片，然后行荧光显微观察，分析两组种?蔡灞砻娴墓浅粱?率（bone mineral apposition rate，MAR）、骨面积率（bone area ratio，BAR）、骨接触率（bone to implant contact，BIC）是否存在差异。结果荧光显微观察显示两组种植体周围均有广泛新骨形成。种植术后第7天至53天，Mg-HA组的MAR、BAR大于HA组，但两者间无显著差异（P>0.05）。术后第7天和第28天，Mg-HA组的BIC大于HA组，两者间有显著差异（P＜0.05）。结论与HA涂层相比，Mg-HA涂层可促进种植体的早期骨结合。

关键词: 种植体, 掺镁羟基磷灰石（Mg-HA）, 羟基磷灰石（HA）, 骨结合

Abstract: Abstract： Objective To evaluate the effect of magnesium-substituted hydroxyapatite coating on peri-implant osseointegration using fluorescent microscope analysis. Methods 20 implants were separated into two groups equally.Ten implants in one group were coated with magnesium-ubstituted hydroxyapatite (Mg-HA); the other ten implants were coated with normal hydroxyapatite (HA) as control group.Both coatings were made using electrochemical deposition technology.All the implants were placed in the femur of adult rabbits.Oxytetracycline hydrochloride was given on the 7th day after operation,and alizarin-complexon was applied on the 28th day after operation,and calcein green was given on 46th day after operation.After 8 weeks,all the rabbits were sacrificed and all the samples collected from the femurs were observed with fluorescent microscope.The bone mineral apposition rate (MAR),bone area ratio (BAR) and bone to implant contact (BIC) were analyzed to indicate the difference of two types of implants.Results Peri-implant newly formed bone was observed in each group.From 7th to 53rd day after operation,the values of MAR and BAR in Mg-HA group were higher than those in HA group.However,no significant difference could be found (P>0.05).On 7th and 28th day,the BIC value of Mg-HA group was significantly higher than that of HA group (P＜0.05).Conclusions Compared with HA coating,Mg-HA coating could have more effect on enhancing peri-implant osseointegration.

Key words: implant, magnesium-substituted hydroxyapatite（Mg-HA）, hydroxyapatite（HA）, osseointegration

中图分类号:

R782.1

史月华谷志远郑园娜何福明谷子芽. 掺镁羟基磷灰石涂层对种植体骨结合的影响[J]. 口腔医学, 2014, 34(4): 249-249.

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