血清SCC-Ag的变化对口腔鳞状细胞癌患者预后的影响

›› 2014, Vol. 34 ›› Issue (5): 350-352.

血清SCC-Ag的变化对口腔鳞状细胞癌患者预后的影响

李海如¹,郑健²,吴蕾²,华春清²,卞晓蓉²

1. 江苏省盐城市第一人民医院
2. 江苏省盐城市第一人民医院口腔科

收稿日期:2013-08-09 修回日期:2013-10-24 出版日期:2014-05-28 发布日期:2014-06-04
通讯作者: 李海如 E-mail:lighw@sohu.com

The effects of changes of serum SCCAg levels on prognosis of oral cavity squamous cell carcinoma

Received:2013-08-09 Revised:2013-10-24 Online:2014-05-28 Published:2014-06-04
Contact: Hai-Ru LI E-mail:lighw@sohu.com

摘要/Abstract

摘要： 目的研究血清鳞状细胞癌抗原(SCC-Ag)水平的变化对口腔鳞癌患者预后的影响。方法采用ELISA检测了58例口腔鳞状细胞癌（鳞癌）患者手术前后血清SCC-Ag水平的改变。结果术前及术后血清SCC-Ag值<1.5 μg/L的口腔鳞癌患者术后发生复发或转移发生率为15.6%和3.1%；术前和术后血清SCC-Ag水平>1.5 μg/L的口腔鳞癌患者术后发生复发或转移发生率为83.3%和95.5%；术前血清SCC-Ag水平>1.5 μg/L的口腔鳞癌患者术后血清SCC-Ag水平下降且SCC-Ag值<1.5 μg/L，其术后复发或转移发生率为25%。结论血清SCC-Ag可能与口腔鳞癌的发生发展有关，其结果可作为判断患者病情的进展及肿瘤是否复发或转移。

关键词: 口腔鳞状细胞癌, 鳞状细胞癌抗原, 手术, 预后

Abstract: Objective To investigate the effects of changes of serum squamous cell carcinoma antigen(SCCAg) levels on prognosis of oral cavity squamous cell carcinoma.Methods The changes of serum SCCAg levels in oral cavity squamous cell carcinoma patients before and after operation were detected by ELISA.Results The incidences of recurrence or metastasis in patients whose serum SCCAg value <1.5 μg/L before and after operation were 15.6% and 3.1%; the incidences of recurrence or metastasis in patients whose serum SCCAg value >1.5 μg / L before and after operation were 83.3 percent and 95.5 percent; as for the patients whose preoperative serum SCCAg level >1.5 μg / L,their serum SCCAg levels fell and the postoperative SCCAg value <1.5 μg / L,and the recurrence or metastasis rate was 25%.Conclusions Serum SCCAg may be related to the development of oral squamous cell carcinoma,and the results can be used to evaluate the progress of the patient's conditions and the recurrence or metastasis of the tumor.

Key words: oral cavity squamous cell carcinoma, squamous cell carcinoma antigen, operation, prognosis

李海如郑健吴蕾华春清卞晓蓉. 血清SCC-Ag的变化对口腔鳞状细胞癌患者预后的影响[J]. 口腔医学, 2014, 34(5): 350-352.

参考文献

[1]于亚峰，姚齐.鳞状细胞癌相关抗原与头颈部肿瘤[J].临床耳鼻咽喉科杂志,2005,19(3):142-144
[2]李海如，郑健，陈亚明，等.口腔鳞癌患者血清催乳素的变化对预后的影响[J].口腔医学,2004,24(5):272-273
[3] 周扬，高静，贾兴旺，等.鳞癌相关抗原在鳞癌及相关良性疾病中的临床意义[J]. 标记免疫分析与临床，2010,17(3).137-140
[4]中华口腔医学杂志编辑部.唇和口腔癌的TNM临床分期[J].中华口腔医学杂志,2006,41(8):466-466
[5] 李斌，周海中，曹剑霞.SCC-Ag、CA19-9、CEA在肺癌患者血清中的变化及临床意义[J]. 放射免疫学杂志，2007,20(5).464-466
[6]万锦平，黄建安，刘皓，等.血清SCC-Ag、CYFRA21-1、NSE、CEA联合检测对肺癌的诊断价值[J].临床肺科杂志,2007,2:111-112
[7]尹林，孙凯莹，许扬，等.口腔鳞状细胞癌患者血清TSGF、SCC-Ag、CEA的表达及其临床意义[J].口腔医学,2011,31(6):334-345
[8]Yan F,Zhou J,Ma J C,et al.Metabolic effects of a novel bioartificial liver on serum from severe hepatitis patients:an in vitro study[J].ChinMedEngl,2003,116(10):1471-1474
[9]朱鸿,王旭,徐裕海,等.应用ROC曲线分析SCC-Ag在宫颈鳞癌中的临床价值[J].大连医科大学学报,2009,31(2):210-212
[10]Nishi N,Miyazaki M,Tsuji K,et al.Squamous cell carcinoma related antigen(SCC-Ag) in children with acute asthma[J].Ann Allergy Asthma Immunol,2005,94:391-397
[11]陈俊,楼跃民.血清SCC增高与上呼吸道感染的关系探讨[J].放射免疫学杂志,2010,6:707-708
[12]Yuyama N,Davies D E,Akaiwa M,et al.Analysis of novel disease related genes in bronchial asthma[J].Cytokine,2002,19(6):287-296
[13]丁湘彧，张宝秋，张洁，等.肺癌患者血清中肿瘤标志物检测的临床意义[J].中华临床医师（电子版,2011,5(16):4646-4650
[14]叶涛，徐浩，吴秋莲，等.血清SCC-Ag、CEA、CA153-3联合检测在肺癌诊断的临床应用标记免疫分析与临床[J].,2010,17(3):182-183
[15]卞京文,黄谦,郭媛,等.SCC-Ag在肺癌患者血清中表达的临床意义[J].临床肺科杂志,2007,11:1210-1211
[16]陈谦,钱建升,姜缨,等.鳞癌患者血清中鳞状细胞癌抗原表达的临床意义[J],中国临床医学,2004,11(4):651-652
[17]吴向陇,姜缨,李明众,等.宫颈鳞状细胞癌患者血清鳞状细胞癌抗原变化的临床意义[J].陕西肿瘤医学,2000,8(2):72-74