转录抑制因子Snail在口腔鳞状细胞癌中的表达及其与临床病理特征及预后多因素的关系

›› 2014, Vol. 34 ›› Issue (6): 401-404.

• 基础与临床研究 • 下一篇

转录抑制因子Snail在口腔鳞状细胞癌中的表达及其与临床病理特征及预后多因素的关系

郑阳玉¹,张涛¹,刘来奎²,张智泓³

1. 南京医科大学附属口腔医院
2. 江苏省口腔医院
3. 南京医科大学第一附属医院

收稿日期:2014-01-07 修回日期:2014-02-24 出版日期:2014-06-28 发布日期:2014-07-07
通讯作者: 郑阳玉 E-mail:nydkys@126.com
基金资助:
国家自然科学基金项目

The investigation of the relationship between expression of Snail in oral squamous cell carcinoma and its clinical factors as pathological characteristics and tumor prognosis

Received:2014-01-07 Revised:2014-02-24 Online:2014-06-28 Published:2014-07-07

摘要/Abstract

摘要： 目的研究转录抑制因子Snail在口腔鳞状细胞癌(以下简称口腔鳞癌)中的表达及其与多种临床病理因素之间的关系，探讨其在口腔鳞癌治疗及预后评估中的意义。方法采用免疫组织化学染色半定量的方法检测83例术前未接受放、化疗或其他特殊治疗的原发性口腔鳞癌患者标本中Snail的表达情况，并对其与口腔鳞癌患者的临床病理因素、转移及预后之间的关系进行统计学分析。结果 83例口腔鳞癌组织标本中，Snail的表达率为89.2%，其中，高表达率为49.4%，低表达率为39.8%。口腔鳞癌组织中Snail的表达水平与患者的性别、年龄、肿瘤分化程度、肿瘤大小、临床分期及淋巴结转移之间在统计学上无显著性差异（P>0.05）。Snail表达水平与口腔鳞癌患者的复发之间有显著性差异（P＝0.003）。结论口腔鳞癌患者癌组织中Snail的高表达与肿瘤复发及预后之间有一定相关关系。因此，Snail有可能作为口腔鳞癌患者复发和预后的预测指标。

关键词: Snail, 口腔鳞状细胞癌, 免疫组织化学

Abstract: Abstract: Objective To investigate the expression of Snail in oral squamous cell carecinoma (OSCC) and it′s correlation with clinic opathologic parameters,in order to investigate its meaning in OSCC treatment and tumor prognosis,and to find biological marker for estimating OSCC recurrence,metastasis and prognosis. Methods Samples from 83 patients with OSCC were studied with semiquantitative immunohistochemistry method.The expression of Snail was examined,and it was combined with clinicopathologic parameter to analyze recurrence rate after operation and mortality rate and prognosis. Results Our study showed that the expression of Snail was negative in normal epithelial tissue while the high expression of Snail was observed in 89% patients with OSCC in the nucleus or cytoplasmic.The expression of Snail was not observed in only 11% patients.There were no statistically significant differences between the expression levels of Snail in the tumor of OSCC and sex,age,histological differentiation,tumor size,clinical stage,or lymph node metastasis(P>0.05).There was a statistically significant increase in the expression levels of Snail with recurrence (P=0.003). Conclusions This study has found the close relationship between high expression of Snail in oral carcinoma and the recurrence and prognosis.High expression of Snail may provide a useful prognostic marker in OSCC patients.

Key words: Snail, oral mucosa squamous cell carcinoma, immunohistochemistry

中图分类号:

R781.5

郑阳玉张涛刘来奎张智泓. 转录抑制因子Snail在口腔鳞状细胞癌中的表达及其与临床病理特征及预后多因素的关系[J]. 口腔医学, 2014, 34(6): 401-404.

参考文献

[1]Forastiere AA,Ang K,Brizel D,et al.Head and neck cancers[J].J Natl Compr Canc Netw,2005,3(3):316-391
[2]Hunter KD,Parkinson EK,Harrison PR.Profiling early head and neck cancer[J].Nat Rev Cancer,2005,5(2):127-135
[3]Casiglia J,Woo SB.A comprehensive review of oral cancer[J].Gen Dent,2001,49(1):72-82
[4]Come C,Magnino F,Bibeau F,et al.Snail and slug play distinct roles during breast carcinoma progression[J].Clin Cancer Res,2006,12(18):5395-5402
[5]Elloul S,Elstrand MB,Nesland JM,et al.Snail,Slug,and Smad interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma[J].Cancer,2005,103(8):1631-1643
[6]Roy HK,Kunte DP,Koetsier JL,et al.Chemop revention of colon carcinogenesis by polyethylene glycol:suppression of epithelial proliferation via modulation of SNAIL /βcatenin signaling[J].Mol Cancer Ther,2006,5(8):2060-2069
[7]Natsugoe S,Uchikado Y,Okumura H,et al.Snail p lays a key role in Ecadherinpreserved esophageal squamous cell carcinoma[J].Oncol Rep,2007,17(3):517-523
[8]Thomson S,Buck E,Petti F,et al.Epithelial to mesenchymal transition is a determinant of sensitivity of nonsmallcell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition[J].Cancer Res,2005,65(20):9455-9462
[9]Chui X,Egami H,Yamashita J,et al.Immunohistochemical expression of the ckit protooncogene product in human malignant and nonmalignant breast t10s[J].Br J Cancer,1996,73(10):1233-1236
[10]Engels K,Knauer SK,Metzler D,et al.Dynamic intracellular survivin in oral squamous cell carcinoma:underlying molecular mechanism and potential as an early prognostic marker[J].J Pathol,2007,211(5):532-540
[11]Pyo SW,Hashimoto M,Kim YS,et al.Expression of Ecadherin,Pcadherin and Ncadherin in oral squamous cell carcinoma:correlation with the clinicopathologic features and patient outcome[J].J Craniomaxillofac Surg,2007,35(1):1-9
[12]Franz M,Spiegel K,Umbreit C,et al.Expression of Snail is associated with myowbroblast phenotype development in oral squamous cell carcinoma[J].Histochem Cell Biol,2009,131(6):651-660
[13]Mahomed F,Altini M,Meer S.Altered Ecadherin/ bcatenin expression in oral squamous carcinoma with and without nodal metastasis[J].Oral Dis,2007,13(4):386-392
[14]Bryne M,Koppang HS,Lilleng R,et al.Malignancy grading of the deep invasive margins of oral squamous cell carcinomas has high prognostic value[J].J Pathol,1992,166(4):375-381
[15]Woolgar JA.Histopathological prognosticators in oral and oropharyngeal squamous cell carcinoma[J].Oral Oncol,2006,42(3):229-239
[16]Ikenouchi J,Matsuda M,Furuse M,et al.Regulation of tight junctions during the epitheliummesenchyme transition :direct repression of the gene expression of claudins/ occludin by Snail[J].J Cell Sci,2003,116(10):1959-1967
[17]Batlle E,Sancho E,Franci C,et al.The transcription factor Snail is a repressor of Ecadherin gene expression in epithelial tumor cells[J].Nat Cell Biol,2000,2(2):84-89
[18]Blanco MJ,MorenoBueno G,Sarrio D,et al.Correlation of Snail expression with histological grade and lymph node status in breast carcinomas[J].Oncogene,2002,21(20):3241-3246
[19]Usami Y,Satake S,Nakayama F,et al.Snailassociated epithelialmesenchymal transition promotes oesophageal squamous cell carcinoma motility and progression[J].Journal of Pathology,2008,215(3):330-339
[20]张阿丽,王全胜,陈刚,等.SNAIL 与Ecadherin 在上皮性肿瘤中的表达及其临床意义[J].肿瘤,2006,26(5):469-471

转录抑制因子Snail在口腔鳞状细胞癌中的表达及其与临床病理特征及预后多因素的关系

The investigation of the relationship between expression of Snail in oral squamous cell carcinoma and its clinical factors as pathological characteristics and tumor prognosis

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