Y-TZP氧化锆植入体的推出实验研究

›› 2014, Vol. 34 ›› Issue (7): 512-516.

Y-TZP氧化锆植入体的推出实验研究

孙伟¹,徐耀卿¹,李晶¹,吴琦²,马冰³,艾红军¹

1. 中国医科大学口腔医学院
2. 辽宁爱尔创生物材料有限公司
3. 中国医科大学附属第一医院临床流行病与循证医学教研室

收稿日期:2013-11-27 修回日期:2013-12-23 出版日期:2014-07-28 发布日期:2014-08-04
通讯作者: 艾红军 E-mail:13940066221@163.com
基金资助:
新型钛种植体表面改性及影响基因表达的研究;锆基金属玻璃牙种植体开发及临床应用研究

The push-out test of Y-TZP zironcia implant material

Received:2013-11-27 Revised:2013-12-23 Online:2014-07-28 Published:2014-08-04

摘要/Abstract

摘要： 目的研究氧化锆种植体材料及新涂层处理方法对骨结合的影响，为该种植体系统开发及应用提供依据。方法选择未加涂层的氧化锆试件、10%多孔涂层氧化锆试件，并分别编为1号、2号，将其植入健康成年雄性新西兰白兔股骨区，每侧股骨各植入2枚试件（长度10 mm，直径2 mm）。采用推出实验评测试件-骨结合的程度，扫描电镜观察试件-骨之间的界面及其成分。结果 4周（t=103.345，P<0.001）、12周（t=24.251，P<0.001）、26周（t=20.854，P<0.001）推出实验结果两组间均有统计学差异。扫描电镜结果显示试件与骨形成较好骨结合，并观察到经过表面处理的试件表面与骨组织间有类似“骨突”样结构。结论氧化锆种植体材料在实验动物体内能够获得稳定的骨结合，多孔涂层处理方法有助于促进骨结合形成。

关键词: 关键词：氧化锆 , 种植体, 推出实验, 骨结合

Abstract: Objective To investigate the influence of new zirconia implant and surface modified method on the osseointegration to provide evidence for the development and application of the implant . Method Healthy adult New Zealand White male rabbits received two types of implant with identical geometry on the femur: sintered zironcia implant for NO.1,zirconia implant with 10% porous coating for NO.2. Each animal received two types of implant and then healed for three time periods （4,12,and 26 weeks）. At each healing time, a push-out test was performed to assess implants stability ,while scanning electron microscopy analysis（SEM）was performed to scan the bone-implant interface. Results Two independent samples t test analysis revealed that there were statistical differences between the two groups at each healing period(4 week t=103.345，P<0.001;12 week t=24.251，P<0.001;26 week t=20.854，P<0.001).Remarkable osseointegrationwas seen with sintered zironcia implant and 10% porous coating zironcia implant. Conclusion The new zirconia implant and surface modified method can enhance the osseointegration.

Key words: Key words: Zirconia , implant, Push-out test , Osseointegration

中图分类号:

R783.1

孙伟徐耀卿李晶吴琦马冰艾红军. Y-TZP氧化锆植入体的推出实验研究[J]. 口腔医学, 2014, 34(7): 512-516.

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