类风湿性骨病与牙周炎的病因机制相关性研究进展

摘要/Abstract

摘要： [摘要] 类风湿性骨性疾病大体包括类风湿性关节炎和强直性脊柱炎。这两种类风湿性骨病与牙周炎都是自身免疫相关性疾病，牙周炎人群中类风湿性骨病的发病率增加，类风湿性骨病患者牙周炎发病率同样增高。究其原因，牙周炎与类风湿性骨病在病因机制方面存在共同之处。本文就类风湿性骨病与牙周炎患病与治疗相关性，造成发病部位炎性表现和骨质改变的原因、机理进行综述。希望以此增加多学科的联合以及对牙周病的深入研究提供理论依据。

关键词: 牙周炎, 类风湿性关节炎, 强直性脊柱炎, 相关性

Abstract: Abstract: Rheumatoid arthritis (RA) and Ankylosing spondylitis (AS) are both rheumatoid osteopathic diseases，which are also autoimmune diseases. The prevalence of rheumatoid osteopathic disease is increasing in people suffering from periodontitis and vise versa. The mechanism of periodontitis and rheumatoid osteopathic disease is similar. We explained several aspects of the relationship between rheumatoid osteopathic disease and periodontitis, which emphasized the pathogenesis for inflammatory lesion and destruction of bone. Hereby, multi-disciplinary study is vital and can provide theoretical foundation for periodontal lucubration.

中图分类号:

R780.2

王越林晓萍. 类风湿性骨病与牙周炎的病因机制相关性研究进展[J]. 口腔医学, 2015, 35(3): 229-233.

Yue WANG. Research advancement on relationship of pathogenesis between rheumatoid osteopathic diseases and periodontitis[J]. Stomatology, 2015, 35(3): 229-233.

参考文献

[1] 王琳源，林晓萍，靳赢. RANKL介导的免疫应答在牙周病吸收中的作用[J].中华口腔医学杂志，2013，48（2）：115-118.
[2] Chen HH，Huang N，Chen Y，et a1. Association between a history of periodontitis and the risk of rheumatoid arthritis:a nation wide,population-based,ease-control study[J].Ann Rheum Dis，2013，72(7)：1206-1211.
[3] Wolff B，Berger T，Frese C，et al.Oral status in patients with early rheumatoid arthritis：a prospective，case-control study[J].Rheumatology(Oxford)，2014，53(3)：526-531.
[4] Keller JJ，Kang JH，Lin HC.Association between anktysing spondulitis and chronic periodonttis:a population-based study[J].Arthritis Rheum，2013，65(1): 167-173.
[5] Mercado F，Marshall RI，Klestov AC，et al.Is there a relationship between rheumatoid arthritis and periodontal disease? [J].J Clin Periodontol，2000，27(4)：267-272.
[6] Ogrendik M. Effects of clarithromycin in patients with active rheumatoid arthritis[J].Curr Med Res Opin，2007，23(3)：515–522.
[7] Erciyas K，Sezer U，Ustün K，et al.Effects of periodontal therapy on disease activity and systemic inflammation in rheumatoid arthritis patients[J].Oral Dis，2013，19(4)：394-400.
[8] Queiroz-Junior CM，Bessoni RL，Costa VV，et al. Preventive and therapeutic anti-TNF-α therapy with pentoxifylline decreases arthritis and the associated periodontal co-morbidity in mice[J].Life Sci，2013，93(9-11)：423-428.
[9] Loyola-Rodriguez JP，Martinez-Martinez RE，Abud-Mendoza C，et al.Rheumatoid arthritis and the role of oral bacteria[J].J Oral Microbiol，2010，2: 10.3402/jom.v2i0.5784.
[10] Martinez-Martinez RE，Abud-Mendoza C，Pati?o-Marin N，et al. Detection of periodontal bacterial DNA in serum and synovial fluid in refractory rheumatoid arthritis patients[J].J Clin Periodontol，2009，36(12):1004–1010.
[11] Lundberg K，Wegner N，Yucel-Lindberg T，et al.Periodontitis in RA-the citrullinated enolase connection[J].Nat Rev Rheumatol，2010，6(12）：727–730.
[12] Kinloch AJ，Alzabin S，Brintnell W，et al.Immunization with Porphyromonas gingivalis enolase induces autoimmunity to mammalian α-enolase and arthritis in DR4-IE-transgenic mice[J].Arthritis Rheum，2011，63(12)：3818-3823.
[13] Lange L，Thiele GM，Pichavant M，et al.A116：increased antibody responses to porphyromonas gingivalis in children with anticyclic citrullinated Peptide antibody-positive juvenile idiopathic arthritis[J].Arthritis Rheumatol，2014，66 Suppl 11：S153.
[14] Mori G，Amelio P，Faccio R，et al.The Interplay between the Bone and the Immune System[J].Clin Dev Immunol，2013，2013：720504.
[15] Kim J，Kang S，Kim J，et al.Elevated levels of T helper 17 cells are associated with disease activity in patients with rheumatoid arthritis[J].Ann Lab Med，2013，33(1)：52-59.
[16] 陈淑增，白剑鹏，谢永华等.强直性脊柱炎患者外周血Th17、Treg、Th1免疫失衡及其与疾病活动相关性研究[J].中国免疫学杂志，2013，29(8)：834-838，847.
[17] Okui T，Aoki Y，Ito H，et al.The presence of IL-17+/FOXP3+ double-positive cells in periodontitis[J].J Dent Res，2012，91(6)：574-579.
[18] Zhao L，Zhou Y，Xu Y，et al.Effect of non-surgical periodontal therapy on the levels of Th17/Th1/Th2 cytokines and their transcription factors in Chinese chronic periodontitis patients[J].J Clin Periodontol，2011，38(6)：509-516.
[19] Glowackia AJ，Yoshizawab S，Jhunjhunwala S，et al. Prevention of inflammation mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes[J].Proc Natl Acad Sci U S A，2013，110(46)：18525-18530.
[20] Ertugrul AS，Sahin H，Dikilitas A，et al.Comparison of CCL28，interleukin-8，interleukin-1β and tumor necrosis factor-alpha in subjects with gingivitis，chronic periodontitis and generalized aggressive periodontitis[J].J Periodontal Res，2013，48(1)：44-51.
[21] Ji Y，Yang X，Yang L，et al.Studies on correlation between single-nucleotide polymorphisms of tumor necrosis factor gene and different stages of ankylosing spondylitis[J].Cell Biochem Biophys，2013，67(3)：915-922.
[22] Pers JO，Saraux A，Pierre R，et al.Anti-TNF-alpha immunotherapy is associated with increased gingival inflammation without clinical attachment loss in subjects with rheumatoid arthritis[J].J Periodontol，2008，79(9)：1645-1651.
[23] Ortiz P，Bissada NF，Palomo L，et al.Periodontal therapy reduces the severity of active rheumatoid arthritis in patients treated with or without tumor necrosis factor inhibitors[J].J Periodontol，2009，80(4)：535-540.
[24] Chao TH，Yu HN，Huang CC，et al.Association of interleukin-1 beta（-511C/T）polymorphisms with osteoporosis in postmenopausal women[J].Ann Saudi Med，2010，30(6)：437-441.
[25] 方絮，林晓萍.IL-23/IL-17炎性轴与牙周炎关系的研究进展[J].口腔医学，2014，34(5)：473-476.
[26] 宋雪婧，詹渊博，张瑞敏.IL一17与牙周炎和类风湿性关节炎相关性的研究进展[J]. 国际免疫学杂志，2014，37（1）：44-48.
[27] de Aquino SG，Abdollahi-Roodsaz S，Koenders MI，et al.Periodontal pathogens directly promote autoimmune experimental arthritis by inducing a TLR2- and IL-1-driven Th17 response[J].J Immunol，2014，1；192(9)：4103-4111.
[28] Baeten D，Baraliakos X，Braun J，et al.Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis：a randomised, double-blind, placebo- controlled trial[J].Lancet，2013，382(9906)：1705-1713.
[29] Tyagi AM，Mansoori MN，Srivastava K，et al.Enhanced Immunoprotective Effects by Anti-IL17 Antibody Translates to Improved Skeletal Parameters Under Estrogen Deficiency Compared to Anti-RANKL and Anti-TNFα Antibodies[J].J Bone Miner Res，2014. doi: 10.1002/jbmr.2228.
[30] Zupan J，Jeras M，Marc J.Osteoimmunology and the infl uence of pro-inflammatory cytokines on osteoclasts[J]. Biochemia Medica，2013，23(1)：43–63.
[31] Chen CH，Chen HA，Liao HT，et al.Soluble receptor activator of nuclear factor-kappaB ligand (RANKL) and osteoprotegerin in ankylosing spondylitis：OPG is associated with poor physical mobility and reflects systemic inflammation[J].Clin Rheumatol，2010，29(10)：1155-1161.
[32] 王琳源，林晓萍.RANKL在牙周炎骨吸收中的研究进展[J].口腔医学，2013，33(7)：493-495.
[33] Taylan A，Sari I，Akinci B，et al.Biomarkers and cytokines of bone turnover：extensive evaluation in a cohort of patients with ankylosing spondylitis[J].BMC Musculoskelet Disord，2012，2；13：191.
[34] Stolina M，Adamu S，Ominsky M，et al.RANKL is a marker and mediator of local and systemic bone loss in two rat models of inflammatory arthritis[J].J Bone Miner Res，2005， 20(10)：1756-1765.
[35] Napimoga MN，Benatti BB，Lima FO，et al.Cannabidiol Decreases bone resorption by inhibiting RANK/RANKL expression and pro-inflammatory cytokines during experimental periodontitis in rats[J]. Int Immunopharmacol，2009，9(2)：216-222.
[36] Baharuddin NA，Coates DE，Cullinan M，et al.Localization of RANK,RANKL and osteoprotegerin during healing of surgically created periodontal defects in sheep[J]. J Periodontal Res，2014. Doi：10.1111/jre.12196.
[37] Han X，Lin X，Yu X，et al. Porphyromonas gingivalis infection associated periodontal bone resorption is receptor activator of nuclear factor-kappaB ligand (RANKL)-dependent[J]. Infect Immun，2013，81(5)：1502-1509..