›› 2015, Vol. 35 ›› Issue (3): 234-236.

• 综述 • 上一篇    下一篇

免疫防龋DNA疫苗动物实验研究进展

童辉燕,程敏,李文娟   

  1. 吉林大学口腔医院预防科
  • 收稿日期:2014-03-27 修回日期:2014-05-30 出版日期:2015-03-28 发布日期:2015-03-30
  • 通讯作者: 程敏 E-mail:mincheng550@sina.com

Recent Development of Animal Research on Immunization Anti-caries DNA Vaccine

  • Received:2014-03-27 Revised:2014-05-30 Online:2015-03-28 Published:2015-03-30

摘要: [摘要] 龋病是以变形链球菌为主要致龋菌引起的口腔感染性疾病。有效地诱导机体产生针对变形链球菌的系统免疫和粘膜免疫,阻止细菌在牙面的粘附与聚集以及细菌在口腔内定植,是防止致龋菌感染的有效手段。应用于免疫防龋研究主要有主动免疫防龋和被动免疫防龋。本文主要论述主动免疫防龋疫苗中的防龋DNA疫苗的优缺点、研究进展及未来的发展前景。

关键词: DNA疫苗, 靶向防龋, 粘膜免疫, 佐剂和运载系统

Abstract: 【Abstract】 Dental caries is one of the most common bacterial infections, which is mainly caused by Mutans Streptococci. Effectively inducing the organism to produce systemic immunity and mucosal immunity against Mutans Streptococci, thus preventing bacterial adhesion and aggregation in the tooth surfaces and bacterial colonization in the oral cavity, is an effective way of preventing cariogenic bacteria infection. Immunization against dental caries mainly includes active immunization and passive immunization. The advantages and disadvantages, research progress and future prospects of Anti-caries DNA vaccine are mainly discussed in this article.

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