牙周病与类风湿性关节炎相关性的病例-对照研究的Meta分析

摘要/Abstract

摘要： 目的采用Meta分析的方法评价牙周病（PD）与类风湿性关节炎（RA）的发病风险关系。方法计算机检索PubMed、EMbase、中国生物医学文献数据库、中国知网、维普及万方数据库，查找国内外公开发表关于PD与RA发病风险关系的病例-对照研究，检索时限均为从建库至2014年5月20日，同时追溯纳入文献的参考文献。由2位研究者根据纳入与排除标准独立选择文献、提取资料和质量评价后，采用CMA v2软件进行Meta分析。结果最终共纳入9个病例-对照研究，2篇中文文献，7篇英文文献，其中RA组465例，健康对照组421例。Meta分析结果显示暴露于PD可以显著提高RA发生率2.81倍［OR=2.81，95%CI（1.41~5.60），P=0.003］，敏感性分析显示结果稳健性较好。无明显发表偏倚存在。结论 PD是RA的一个有意义的危险因子。应进一步进行按PD临床程度分级和RA临床亚型分型的研究。

关键词: 牙周病, 类风湿性关节炎, Meta分析, 病例-对照研究, 危险因子

Abstract: Objective To investigate the relationship between periodontal disease (PD) and risk of rheumatoid arthritis (RA) by performing a metaanalysis.Methods Such databases as PubMed,EMbase,CBM,CNKI,and WanFang databases were searched from their inception to May 20th,2014 to collect casecontrol studies about the PD and risk of RA,and the relevant references of the included literature were also retrieved.Two reviewers independently screened the literature according to the inclusion and exclusion criteria,extracted the data,and assessed the methodological quality.Then metaanalysis was conducted using CMA v2 software.Results Eventually nine casecontrol studies were included,2 in Chinese literature,7 articles in English literature,including RA group 465 cases and 421 cases of normal control group.The metaanalysis showed that exposure to PD could obviously increase incidence of rheumatoid arthritis 2.81 times (OR=2.81,95% CI 1.41 to 5.60,P=0.003),and sensitivity analysis showed the results were robust.There was no publication bias existing.Conclusions PD is an independent and significant factor to AR.Further studies according to the degrees of PD and the clinical subtypes of rheumatoid arthritis should be carried out.

Key words: periodontal disease, rheumatoid arthritis, Metaanalysis, casecontrol study, risk factor

中图分类号:

R781.4

席晨希周群罗敏. 牙周病与类风湿性关节炎相关性的病例-对照研究的Meta分析[J]. 口腔医学, 2015, 35(4): 291-295.

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