铁调素及其与骨代谢的研究进展

›› 2015, Vol. 35 ›› Issue (4): 314-317.

铁调素及其与骨代谢的研究进展

张千依,郭婧芳,唐冠群,朱宪春

吉林大学口腔医院

收稿日期:2014-11-27 修回日期:2014-12-23 出版日期:2015-04-28 发布日期:2015-04-27
通讯作者: 张千依 E-mail:1026810450@qq.com
基金资助:
吉林省卫生厅科研计划

Advance in the research of hepcidin and its role in bone metabolism

Received:2014-11-27 Revised:2014-12-23 Online:2015-04-28 Published:2015-04-27

摘要/Abstract

摘要： 铁调素（Hepcidin）是一类调节机体铁稳态的抗菌多肽,由HAMP基因编码，大量研究表明血清中铁的含量、骨形成蛋白（BMPs）、白介素-6（IL-6）及低氧诱导因子（HIF）等可调控铁调素的表达；最新研究表明其与骨代谢相关,铁调素可通过“铁调素-铁代谢-骨代谢”和“JAK／STAT”信号通路这两种途径影响骨代谢。该文就铁调素的生成机制及其在骨代谢中作用的相关研究进行综述。

关键词: 铁调素, 骨代谢, 骨形成蛋白, “JAK／STAT”信号通路

Abstract: Hepcidin is a kind of antimicrobial peptide regulating organic iron homeostasis,and it is encoded by HAMP gene.Concerning the generating mechanism of hepcidin,the content of serum iron,bone morphogenetic proteins(BMPs),interleukin6(IL6),hypoxiainducible factor(HIF)or other signaling factors can regulate its expression.The latest study indicates that hepcidin is involved in bone metabolism.It affects bone metabolism process through the “hepcidiniron metabolism bone metabolism”and “JAK/STAT”signaling pathway.This articlereviews relevant researchesofhepcidin generation mechanism and its relationship with bonemetabolism .

Key words: hepcidin, bone metabolism, bone morphogenetic proteins, “JAK/STAT”signaling pathway

中图分类号:

R341.8

张千依郭婧芳唐冠群朱宪春. 铁调素及其与骨代谢的研究进展[J]. 口腔医学, 2015, 35(4): 314-317.

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