匹配牙槽窝的根形种植体即刻种植的动物实验研究

摘要/Abstract

摘要： 目的探讨更加完善成熟的即刻种植技术和方法。方法选用当地生产杂种犬9只，采用自身对照方式，拔除所有动物下颌双侧第三、四前磨牙，每个前磨牙均为2个根即近中根与远中根，在右侧第三、四前磨牙远中根拔牙窝、左侧第三、四前磨牙近中根拔牙窝，直接植入直径与拔牙窝相匹配的种植体为Sim组；在左侧第三、四前磨牙远中根拔牙窝，采用直径小于拔牙窝的种植体和Bio-oss骨粉联合植入为Bio组。分别于术后1个月、2个月、3个月随机处死3只实验动物，制成HE染色组织切片，做光镜及骨组织形态计量学观察。结果 Sim组种植体成功率高。光镜观察Sim组骨板连续性较好、较厚、周围有大量成骨细胞。骨组织形态计量学观察：Sim组在1个月时的骨性结合率（CLF）、界面新骨生长率(BIF)均大于Bio组，两组之间有显著的统计学差异﹙P＜0.05﹚，Sim组在2个月、3个月时的骨性结合率，界面新骨生长率均稍大于Bio组，两组之间无显著的统计学差异(P＞0.05)。结论直接植入与牙槽窝相匹配的根形种植体可加速种植体的骨性结合，其骨结合率高于种植体周围骨缺损充填Bio-oss骨粉。

关键词: 纯钛种植体, 骨性结合, 即刻种植 , Bio-oss骨粉, 犬

Abstract: Abstract： Objective To explore the better and mature technique of immediate implantation.Methods Animal experiments:Nine rural adult mongrel dogs were used in this study.Self-contrast was adopted.Mandibular third and fourth premolars were extracted bilaterally on all animals.Each premolar had two roots which were medial root and distal root.The implants with the same diameter as extraction sockets were placed into right mandibular third,fourth premolar distal extraction sockets and left mandibular third,and fourth premolar medial extraction sockets (Sim group); The implants with the smaller diameter than extraction sockets were placed into left mandibular third and fourth premolar distal extraction sockets.The space around the defects was filled with Bio-oss(Bio group).The dogs were killed randomly at 1st month,2nd months,3rd months after surgery.The tissue samples were stained with HE for histological examination and bone histomorphometric parameters were measured to quantify the change of new bone around titanium implants and to observe the changes of implant-bone interface.Results The success rate of Sim group was higher than that of Bio group.The bone plate of sim group was better in continuity,thicker and surrounded by a large number of osteoblasts.At 1st month after surgery,contact length fraction (CLF),bone ingrowth fraction (BIF) in Sim group have significantly increased compared with those in Bio group (P＜0.05).At 2nd,3rd months after surgery,contact length fraction (CLF),bone ingrowth fraction (BIF) in Sim group slightly increased compared with Bio group,but there was no significant difference between two groups (P＞0.05).Conclusions Using root-shaped implants with the same diameter as extraction sockets could accelerate osseointegration,and the CLF was higher than that in the defects around implants covered with Bio-oss.

Key words: pure titanium implant, osseointegration, immediate implant, Bio-oss, dog

中图分类号:

　R782.1

杜义军董福生栗兴超张雪敏. 匹配牙槽窝的根形种植体即刻种植的动物实验研究[J]. 口腔医学, 2015, 35(9): 721-725.

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