LIM矿化蛋白1在牙髓干细胞和骨髓间充质干细胞中的研究进展

摘要/Abstract

摘要： LIM矿化蛋白1(LMP1）是一种胞内信号转导分子,体内外研究表明它在成骨细胞分化过程中起到促进骨形成的重要作用。目前认为LMP1 是通过刺激某些诱导骨形成的因子如骨形态发生蛋白（BMP）的合成及分泌发挥作用,从而提高骨形态发生蛋白及其他成骨因子的成骨活性。该文围绕LMP1的作用及在牙髓干细胞和骨髓间充质干细胞矿化方面的研究现状作一综述。

关键词: LIM矿化蛋白1, 骨形态发生蛋白, 牙髓干细胞, 骨髓间充质干细胞

Abstract: The LIM mineralization protein1 (LMP1) is a kind of intracellular signal transduction molecule which plays an important role in facilitating bone formation during the process of osteoblast differentiation according to both in vivo and in vitro studies. So far, it has been believed that LMP1 functions by stimulating the synthesis and secretion of certain factors like bone morphogenetic protein (BMP) which can induce bone formation, thus improving the osteogenic activity of BMP and other osteogenic factors. This article reviewed the role of LMP1 and the research progress concerning the mineralization of dental pulp stem cells (DPSC) and bone marrow stromal cells (BMSC).

Key words: LIM mineralization protein1, BMP, DPSC, BMSC

中图分类号:

R780.2

费腾胡伟平袁梦桐. LIM矿化蛋白1在牙髓干细胞和骨髓间充质干细胞中的研究进展[J]. , 2016, 36(3): 285-288.

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