关键词: β-防御素, TOLL样受体, 慢性牙周炎

Abstract: Abstract: Objective: To study the expression of hBDs and TLRs in periodontal tissues and the changes of the expression level in chronic periodontitis. Methods: 23 chronic periodontitis patients and 15 healthy controls were collected in the Department of Stomatology. The periodontal tissues were collected in the patients with chronic periodontitis and healthy controls. The expression levels of TLRs and hBDs were analyzed by real-time quantitative PCR and immunohistochemistry. Results: the expression levels of TLRs and hBDs in the periodontal tissues of healthy individuals and patients with chronic periodontitis were varied, but the change trend was different. Conclusions: the expression levels of TLRs in the periodontal tissues were analyzed by this study. According to the research results, the expression level of endogenous immune factor in the periodontal tissues of the two kinds of endogenous immune factors may change with the presence of periodontitis. Because of the different expression of the site, it is suggested that there are interactions between these two endogenous immune factors in the process of chronic periodontitis.

Key words: hBDs, TLRs, periodontitis