釉基质蛋白对牙周细胞抗炎作用的研究进展

›› 2016, Vol. 36 ›› Issue (6): 569-572.

釉基质蛋白对牙周细胞抗炎作用的研究进展

陆嘉玲,束蓉

上海交通大学医学院附属第九人民医院

收稿日期:2015-12-17 修回日期:2016-03-08 出版日期:2016-06-28 发布日期:2016-06-30
通讯作者: 束蓉 E-mail:shurong123@hotmail.com
基金资助:
国家自然科学基金面上项目

Research progress of the anti-inflammatory effect of EMP on periodontal cells

Received:2015-12-17 Revised:2016-03-08 Online:2016-06-28 Published:2016-06-30

摘要/Abstract

摘要： ［摘要］　釉基质蛋白（enamel matrix protein，EMP）促进牙周组织再生的作用已得到大量研究证实。近来，随着EMP的研究进展，其抗炎作用也逐渐被发现。本文就EMP对多种牙周相关细胞的抗炎作用作一综述。

关键词: 釉基质蛋白, 牙周细胞, 抗炎

Abstract: Abstract: It has been widely proved that enamel matrix protein (EMP) can enhance periodontal regeneration. Recently, the anti-inflammatory effect of EMP has also been discovered in many relevant studies. The article reviewed the current research process of the anti-inflammatory activity of EMP on several periodontal cells.

Key words: Enamel matrix protein, Periodontal cells, Anti-inflammation

中图分类号:

R780.2

陆嘉玲束蓉. 釉基质蛋白对牙周细胞抗炎作用的研究进展[J]. , 2016, 36(6): 569-572.

参考文献

[1]. Sakoda, K., Y. Nakajima, and K. Noguchi, Enamel matrix derivative induces production of vascular endothelial cell growth factor in human gingival fibroblasts. Eur J Oral Sci, 2012. 120(6): p. 513-9.
[2]. Villa, O., et al., Subfractions of enamel matrix derivative differentially influence cytokine secretion from human oral fibroblasts. J Tissue Eng, 2015. 6: p. 2041731415575857.
[3]. 邹慧儒，秦宗长，张兰成, 釉基质蛋白各组成成分及其作用. 国际腔医学杂志, 2013. 40(3): p. 355-25.
[4]. Ono, M., et al., Quest for anti-inflammatory substances using IL-1beta-stimulated gingival fibroblasts. In Vivo, 2011. 25(5): p. 763-8.
[5]. Sanchez, G.A., et al., Salivary IL-1beta and PGE2 as biomarkers of periodontal status, before and after periodontal treatment. J Clin Periodontol, 2013. 40(12): p. 1112-7.
[6]. Sato, S., et al., Enamel matrix derivative exhibits anti-inflammatory properties in monocytes. J Periodontol, 2008. 79(3): p. 535-40.
[7]. Khedmat, S., et al., Effects of enamel matrix derivative on the viability, cytokine secretion, and phagocytic activity of human monocytes. J Endod, 2010. 36(6): p. 1000-3.
[8]. Gundersen, R.Y., et al., Systemic administration of enamel matrix derivative to lipopolysaccharide-challenged pigs: effects on the inflammatory response. Surg Infect (Larchmt), 2008. 9(2): p. 161-9.
[9]. Giannopoulou, C., et al., Enamel matrix derivative and systemic antibiotics as adjuncts to non-surgical periodontal treatment: biologic response. J Periodontol, 2006. 77(4): p. 707-13.
[10]. Almqvist, S., et al., Amelogenins modulate cytokine expression in LPS-challenged cultured human macrophages. Cytokine, 2012. 58(2): p. 274-9.
[11]. Myhre, A.E., et al., Anti-inflammatory properties of enamel matrix derivative in human blood. J Periodontal Res, 2006. 41(3): p. 208-13.
[12]. Karima, M.M. and T.E. Van Dyke, Enamel matrix derivative promotes superoxide production and chemotaxis but reduces matrix metalloproteinase-8 expression by polymorphonuclear leukocytes. J Periodontol, 2012. 83(6): p. 780-6.
[13]. Gassmann, G., et al., Influence of enamel matrix derivative on primary CD4+ T-helper lymphocyte migration, CD25 activation, and apoptosis. J Periodontol, 2009. 80(9): p. 1524-33.
[14]. Weinberg, E., et al., Differential effects of prostaglandin E(2) and enamel matrix derivative on the proliferation of human gingival and dermal fibroblasts and gingival keratinocytes. J Periodontal Res, 2010. 45(6): p. 731-40.
[15]. Zeldich, E., et al., Enamel matrix derivative induces the expression of tissue inhibitor of matrix metalloproteinase-3 in human gingival fibroblasts via extracellular signal-regulated kinase. J Periodontal Res, 2010. 45(2): p. 200-6.
[16]. Zeldich, E., et al., Enamel matrix derivative protects human gingival fibroblasts from TNF-induced apoptosis by inhibiting caspase activation. J Cell Physiol, 2007. 213(3): p. 750-8.
[17]. Scheller, J., et al., The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta, 2011. 1813(5): p. 878-88.
[18]. Nokhbehsaim, M., et al., Anti-inflammatory effects of EMD in the presence of biomechanical loading and interleukin-1beta in vitro. Clin Oral Investig, 2012. 16(1): p. 275-83.
[19]. Nokhbehsaim, M., et al., Effects of enamel matrix derivative on periodontal wound healing in an inflammatory environment in vitro. J Clin Periodontol, 2011. 38(5): p. 479-90.
[20]. Deschner, J. and M. Nokhbehsaim, Regulatory effects of inflammatory and biomechanical signals on regenerative periodontal healing. Int J Oral Maxillofac Implants, 2013. 28(6): p. e472-7.
[21]. Miron, R.J., et al., Effect of Enamel Matrix Derivative (EMD)-Liquid on Osteoblast and Periodontal Ligament Cell Proliferation and Differentiation. J Periodontol, 2015: p. 1-14.
[22]. Miron, R.J., et al., Gene array of primary human osteoblasts exposed to enamel matrix derivative in combination with a natural bone mineral. Clin Oral Investig, 2013. 17(2): p. 405-10.