口腔扁平苔藓患者血清IFN-γ、IL-10和IL-17表达分析

›› 2016, Vol. 36 ›› Issue (7): 612-614.

口腔扁平苔藓患者血清IFN-γ、IL-10和IL-17表达分析

张凤格¹,甄蕾²,范德生³,吴新⁴

1. 南京医科大学附属南京医院（南京市第一医院）
2. 上海市口腔病防治院牙周科
3. 同济大学附属同济医院病理科
4. 南京医科大学附属南京医院（南京市第一医院）口腔科

收稿日期:2015-08-03 修回日期:2016-02-03 出版日期:2016-07-28 发布日期:2016-07-19
通讯作者: 张凤格 E-mail:zhfg4261@163.com
基金资助:
上海市自然科学基金面上项目; 上海市卫生局青年基金项目

Expression of IFN-γ, IL-10 and IL-17 in patients with oral lichen planus

Received:2015-08-03 Revised:2016-02-03 Online:2016-07-28 Published:2016-07-19

摘要/Abstract

摘要： 目的观察口腔扁平苔藓（OLP）患者血清中Th型细胞因子IFNγ、IL10和IL17表达，初步探讨其在OLP发生发展中的作用。方法选择2011—2014 年在上海市口腔病防治院口腔内科就诊的OLP 患者15 例，健康志愿者15例，采集静脉血，酶联免疫吸附试验（ELISA）检测血清中IFNγ、IL10和IL17含量。结果实验组、对照组OLP患者血清中Th1型细胞因子IFNγ的含量无显著差异(P>0.05)，Th2型细胞因子IL10含量为（43.3±4.6）、（29.0±5.1）pg/mL，实验组高于对照组（P<0.05）。IFNγ与IL10的比值（即Th1/Th2）为0.418、0.712，实验组较对照组的比值减小。两组Th17型细胞因子IL17含量为（23.6±2.7）、（16.8±3.3）pg/mL，实验组高于正常对照组（P<0.05）。结论 Th型相关细胞因子失衡与OLP的发生发展密切相关。

关键词: 口腔扁平苔藓, 血清, 细胞因子

Abstract: Objective To observe the expression of Th cytokines IFNγ, IL10 and IL17 in serum of patients with oral lichen planus (OLP), and to explore its role in the genesis and development of OLP. Methods 15 patients with OLP and 15 healthy controls participated in the study. Interferon (IFN)γ, interleukin (IL)10 and IL17 levels in serum were examined by enzyme linked immunosorbent assay (ELISA). Results The levels of Th1 cytokines IFNγ in serum of patients with OLP group and healthy controls were （20.8±8.3）pg/mL and （20.6±3.1）pg/mL, respectively, with no statistical difference between groups (P>0.05). The levels of Th2 cytokines IL10 in serum of patients with OLP and healthy controls were （43.3±4.6）pg/mL and （29.0±5.1）pg/mL, respectively, and the difference was statistically significant (P<0.05). The ratio of IFNγ to IL10 was 0.418 for the OLP group and 0.712 for the control group, which demonstrated a decrease in the experimental group compared the control group. The level of Th17 cytokines IL17 in serum of patients with OLP group was （23.6±2.7）pg/mL, which was significantly higher than （16.8±3.3）pg/mL in the control group (P<0.05). Conclusion The change in Th cytokines balance is involved in the pathogenesis of OLP.

Key words: oral lichen planus, serum, cytokine

中图分类号:

R781.5

张凤格甄蕾范德生吴新. 口腔扁平苔藓患者血清IFN-γ、IL-10和IL-17表达分析[J]. , 2016, 36(7): 612-614.

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