药物诱发性天疱疮

›› 2016, Vol. 36 ›› Issue (9): 769-773.

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药物诱发性天疱疮

龚旺¹,魏子豪²,陈谦明³,曾昕⁴

1. 四川大学华西口腔医学院
2. 四川大学
3. 四川大学华西口腔医院
4. 四川大学华西口腔医学院黏膜科；口腔疾病研究国家重点实验室

收稿日期:2016-06-28 修回日期:2016-07-06 出版日期:2016-09-28 发布日期:2016-10-06
通讯作者: 陈谦明 E-mail:00@qq.com

Drug-induced pemphigus

1. West China Scholl of Stomatology, SIchuan Univercity
2.

Received:2016-06-28 Revised:2016-07-06 Online:2016-09-28 Published:2016-10-06
Contact: Chen Qianming E-mail:00@qq.com

摘要/Abstract

摘要： 药物诱发性天疱疮是天疱疮的一种特殊类型，病情一般较轻微，口服诱发药物病情加重或复发，药物与发病过程有着确切的联系。目前报道的药物诱发性天疱疮病例越来越多，诱发药物种类也增多，主要分为巯基类药物和非巯基药物。现大多认为其发病机制与遗传和药物相关，药物发病机制主要体现在生化作用和免疫作用两个方面。临床表现不具特异性，与药物种类相关，主要表现为落叶型和寻常型。新的辅助诊断方法（体外γ-干扰素释放试验）的运用，为确定诱发药物提供了重要的参考信息。32-2B免疫染色为药物诱发性天疱疮的诊断和预后提供有效价值。

关键词: 药物诱发性天疱疮 , 巯基类/非巯基类药物, 体外γ-干扰素释放试验, 32-2B免疫染色

Abstract: Drug-induced pemphigus is a special type of pemphigus. In those cases, the disease is generally mild and will accelerate or relapse after taking the culprit drug again. The drugs have been proved to play a definite role in the pathogenesis of those patients. According currently reports, the number of DIP cases and the types of drugs are increasing, including thiol drugs and nonthiol drugs. In most of studies, researchers consider that its pathogenesis relates to genetic and the culprit drug, and the culprit drug includes both biochemical and immunologic. The clinical manifestations are not specific, relating to the type of drug, and mainly show foliaceus variety and vulgaris variety. New auxiliary diagnostic method (in vitro interferon-gamma release test) has been used to determine the culprit drug and provides an important reference. 32-2B mucosal immunostaining provides important information for the diagnosis and prognosis of drug-induced pemphigus.

Key words: Drug-induced pemphigus, thiol/nonthiol drugs, In vitro interferon-gamma release test, 32-2B mucosal immunostaining

龚旺魏子豪陈谦明曾昕. 药物诱发性天疱疮[J]. , 2016, 36(9): 769-773.

参考文献

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药物诱发性天疱疮

Drug-induced pemphigus

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