糖尿病患者口腔种植治疗研究进展

摘要/Abstract

摘要： 糖尿病患者的日益增长已经成为目前社会的关注的一大问题。持续性高血糖会危害机体各个组织，最终导致糖尿病患者的死亡。口腔组织会受到高血糖所带来的直接负面影响。大多数临床研究表明，即便是在中度不受控的糖尿病患者中，牙种植失败率与非糖尿病患者的差异也并不显著。如果能够实施正确的治疗方案、术前及术后合理使用预防性药物并进行充分的术后维护，受控良好的糖尿病患者与非患病人群拥有同样高的牙种植成功率。本文通过回顾近期糖尿病患者口腔种植研究资料，对糖尿病患者的牙种植治疗做一综述，同时基于改善骨整合的理论及实验研究结果，对提高糖尿病患者牙种植治疗成功率的措施提出一定的建议。

关键词: 牙种植体糖尿病骨整合

Abstract: Rising population of diabetic individuals across the world has become a big concern to the society. The persistent hyperglycemia may harm each tissue of human body and consequently results in morbidity and eventually mortality of diabetic patients. What’s worse, it will have direct negative impacts on oral tissues. Most of clinical studies indicated statistically insignificant failure of dental implants even in moderately uncontrolled diabetic patients, compared with non-diabetic patients. Success of dental implant in well and fairly controlled diabetic patients with proper treatment planning, fair use of prophylactic remedies before and after operation and adequate postsurgical maintenance appears as often as that of normal individuals. This review caters actual scenario to practicing dentists regarding success and failure of dental implant treatment in diabetic individuals observed by various studies. The experience- based suggestions and experimental studies about increasing osteointegration and consequently improving success rate of dental implant treatment in diabetic patients have also been discussed.

Key words: Dental implant, diabetic , osteointegration

中图分类号:

R783.4

李涛. 糖尿病患者口腔种植治疗研究进展[J]. , 2017, 37(11): 1041-1044.

李涛. Research progress of dental implantation in diabetic patients[J]. , 2017, 37(11): 1041-1044.

参考文献

[1]Yang W,Lu J,Wang J,et al.Prevalence of diabetes among men and women in China[J].N Engl J Med,2010,362(25):1090-1101
[2]Vaz NC,Ferreira AM,Kulkarni MS,et al.Prevalence of diabetes mellitus in a rural population of Goa,India[J].Natl Med J India,2011,24(1):16-18
[3] IDF Diabetes Atlas.International diabetes federation[M]. 4th ed. Quebec,Canada: Released at Montreal,2009:19-21
[4]Wang YH,Zhao Q,Tan Z.Current differences in dental education between chinese and western models[J].Eur J Dent Educ,2016,24(1):211-214
[5]Arruda AP,Hotamisligil GS.Calcium homeostasis and organelle function in the pathogenesis of obesity and diabetes[J].Cell Metab,2015,22(3):381-397
[6]Akca G,Yerdelen D,Balc? MK.The effects of hyperventilation on axonal excitability parameters in patients with diabetes mellitus and polyneuropathy[J].Diabetes Res Clin Pract,2016,7(118):112-120
[7]Loe H.Periodontal disease: sixth complication of diabetes mellitus[J].Diabetes Care,1993,(16):329-334
[8]Ganeko K,Masaki C,Shibata Y.Bone aging by advanced glycation end products:amultiscale mechanical analysis[J].J Dent Res,2015,94(21):1684-1690
[9]Atayde SA,Yoshinari NH,Nascimento DP.Experimental diabetes modulates collagen remodelling of joints in rats[J].Histol Histopathol,2012,27(11):1471-1779
[10]Sellmeyer DE,Civitelli R,Hofbauer LC.Skeletal metabolism,fracture risk,and fracture outcomes in type 1 and type 2 Diabetes[J].Diabetes,2016,65(7):1757-1766
[11]Hartmann K,Koenen M,Schauer S.Molecular actions of glucocorticoids in cartilage and bone during health,disease,and steroid therapy[J].Physiol Rev,2016,96(2):409-417
[12]Tatarakis N,Kinney JS,Inglehart M.Clinical,microbiological,and salivary biomarker profiles of dental implant patients with type 2 diabetes[J].Clin Oral Implants Res,2014,25(7):803-812
[13]McCracken MS,Aponte-Wesson R,Chavali R,et al.Bone associated with implants in diabetic and insulin-treated rats[J].Clin Oral Implants Res,2006,(17):495-500
[14]Ardura JA,Portal-Nunez S,Lozano D.Local delivery of parathyroid hormone-related protein-derived peptides coatd onto a hydroxyapatite-based implant enhances bone regeneration in old and diabetic rats[J].J Biomed Mater Res A,2016,104(8):2060-2070
[15]Kayal RA,Tsatsas D,Bauer MA,et al.Diminished bone formation during diabetic fracture healing is related to the premature resorption of cartilages associated with increased osteoclast activity[J].J Bone Miner Res,2007,8(22):560-563
[16]Lu L,Lei L,Wenchuan C.Berberine in combination with insulin has additive effects on titanium implants osseointegration in diabetes mellitus rats[J].Evid Based Complement Alternat Med,2015,23(10):824-829
[17]Sugita Y,Honda Y,Kato I.Role of photofunctionalization in mitigating impairedosseointegration associated with type 2 diabetes in rats[J].Int J Oral Maxillofac Implants,2014,29(6):1293-1300
[18]Molon RS,Morais-Camilo JA,Verzola MH.Impact of diabetes mellitus and metabolic control on bone healing around osseointegrated implants: removal torque and histomorphometric analysis in rats[J].Clin Oral Implants Res,2013,24(7):831-837
[19]Ana MV，Juan C,Ferrer G.Agustin herreraballester，carlos labaig rueda effects of diabetes on the osseointegra-tion of dental implants[J].Med Oral Patol Oral Cir Bucal,2007,12(3):38-43
[20]Li X,Ma XY,Feng YF.Osseointegration of chitosan coated porous titanium ally implant by reactive oxygen spcies-mediated activation of the pi3k/akt pathway under diabetic conditions[J].Biomaterials,2015,36(2):44-54
[21]Ma XY,Feng YF,Ma ZS.The promotion of osteointegration under diabetic conditions using chitosan/hydroxyapatite composite coating on porous titanium surfaces[J].Biomaterials,2014,35(26):7259-7270
[22]Hurst D.Evidence unclear on whethert ype I or II diabetes increases the risk of implant failure[J].Evid Based Dent,2014,15(4):102-103
[23] Moraschini V,Barboza ES.The impact of diabetes on dental implant failure: a systematic review and meta-analysis[J]. Int J Oral Maxillofac Surg,2016 (16):391-397
[24]Moraschini V,Poubel L,Ferreira V,et al.Evaluation of survival and success rates of dental implants reported in longitudinal studies with a follow-up period of at least 10 2015s: a systematic review[J].Int J Oral Maxillofac Surg,2015,44(3):377-388
[25]Oates T,Huynh-Ba G,Vargas A,et al.A critical review of diabetes,glycemic control,and dental implant therapy[J].Clin Oral Implants Res,2013,24(12):117-127
[26]Omran M,Miley D.,McLeod D,et alRetrospective assessment of survival rate for short endosseous dental implants[J].. Implant Dent,2015,24(7):185-191
[27]Boyle JP,Thompson TJ,Gregg EW,et al.Projection of the 2010 2050 burden of diabetes in the us adult population: dynamic modeling of incidence,mortality,and prediabetes prevalence[J].Popul Health Metr,2010,8(29):234-239
[28]Erdogan O,U?ar Y,Tatli U,et al.A clinical prospective study on alveolar bone augmentation and dental implant success in patients with type 2 diabetes[J].Clin Oral Implants Res,2015,26(12):1267-1275
[29]GómezG,AguilarA,RubioJ,et al.Peri-implant evaluation in type 2 diabetes mellitus patients: a 3-2015 study[J].Clin Oral Implants Res,2015,26(8):1031-1035
[30]Olson JW,Shernoff AF,Tarlow JL,et al.Dental endosseous implant assessments in a type 2 diabetic population: A prospective study[J].Int J Oral Maxillofac Implants,2000,(15):811-818
[31]Nobre A,Mao P,Goncalves Y.Outcome of dental implant in diabetic patients with and without cardiovascular disease:a 5- post-loading retrospective study[J]. Eur J Oral Implantol,2016 ，9(1):87-95
[32]Moy PK,Mediana D,Shetty V,et al.Dental implant failure rates and associatedfactors[J].Int J Oral Maxillofac Implants,2005,(20):569-577
[33]Oates TW,Dowell S,Robinson M.Glycemic control and implant stabilization in type 2 diabetes mellitus[J].J Dent Res,2009,88(23):367-371
[34]Alsaadi G,Quirynen M,Komárek A.Impact of local and systemic factors onthe incidence of oral implant failures,up to abutment connection[J].J Clin Periodontol,2007,12(34):610-617
[35]Carr AB.Implant location and radiotherapy are the only factors linked to 2-2010 implant failure[J].J Evid Based Dent Pract,2010,8(10):49-51
[36]Tawil G,Younan R,Azar P,et al.Conventional and advanced implant treatment in the type II diabetic patient: surgical protocol and long-term clinical results[J].Int J Oral Maxillofac Implants,2008,12(23):744-753
[37]Balshi SF,Wolfinger GJ,Balshi TJ.An examination of immediately loaded dental implant stability in diabetic patient using resonance frequency analysis[J].Quintessence Int,2007,12(38):271-279
[38]Telgi RL,Tandon V,Tangade PS.Efficacy of nonsurgical periodontal therapy on glycaemic control in type II diabetic patients: a randomized controlled clinical trial[J].J Periodontal Implant Sci,2013,43(4):177-182
[39]Niedermaier R,Stelzle F,Riemann M.Implant-supported immediate loaded fixed full-arch dentures: evaluation of implant survival rates in a case cohort of up to 7 2016s[J].Clin Implant Dent Relat Res,2016,15(27):281-287
[40]Morris HF,Ochi S,Winkler S.Implant survival in patients with type 2 diabetes:placement to 36 months[J].Ann Periodontol,2000,12(5):157-163
[41]Khandelwal N,Oates TW,Vargas A.Conventional sla and chemically modified sla implants in patients with poorly controlled type 2 diabetes mellitus-a randomized controlled tial[J].Clin Oral Implants Res,2013,24(1):13-19
[42]Shawky AF,Ashour EM.Unsplinted implants retaining a mandibular overdenture with magnetic attachments: a short-term clinical study in controlled type 2 diabetic patients[J].Quintessence Int,2014,45(4):299-305
[43]Accursi GE.Treatment outcomes with osseointegrated branemark implants in diabetic patients: a retrospective study [J][J].University of Toronto,2000,12(6):231-234
[44]Borba AM,Souza DF,Brozoski MA.Can the use of antibiotics interfere with the success of dental osseointegrated implant in diabetic patients?[J].J Contemp Dent Pract,2013,14(6):1197-1201
[45]Marchand F,Raskin A,Dionnes-Hornes A.Dental implants and diabetes:conditions success[J].Diabetes Metab,2012,38(1):14-19
[46]Guimar?es RP,Oliveira PA,Oliveira AM.Effects of induced diabetes and the administration of aminoguanidine in the biomechanical retention of implants: a study in rats[J].Periodontal Res,2011,(46):691-696
[47]Kopman JA,Kim DM,Rahman SS,et al.Modulating the effectsof diabetes on osseointegration with aminoguanidine and doxycycline[J].J Periodontol,2005,34(76):614-620
[48]Chung SM,Jung IK,Yoon BH.Evaluation of different combinations of biphasic calcium phosphate and growth factors for bone formation in calvarial defects in a rabbit model[J].Int J Periodontics Restorative Dent,2016,36(13):49-59
[49]Kartal Y,Ucok C,Ozgul O,et al.Effect of locally applied by FGF on implant stability: biomechanical evaluation of 2different implant surfaces in rabbits[J].Implant Dent,2014,23(4):463-470